Copper-Catalyzed Regioselective 1,2-Alkylesterification of Dienes to Allylic Esters

Organic Letters
Yougui LiHongli Bao

Abstract

Copper catalyzed 1,2-alkylesterification of 1,3-dienes with diacyl peroxides affords branched allylic esters in excellent regioselectivity, including products with a newly generated fully substituted carbon center. The only byproduct is CO2. The reaction proceeds by a radical mechanism as suggested by spin trap and crossover experiments.

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Citations

Dec 13, 2016·Organic Letters·Kaki Raveendra BabuHongli Bao
Apr 30, 2017·Chemical Science·Nengbo ZhuHongli Bao
Jun 20, 2017·Chemistry : a European Journal·Xiaotao ZhuHongli Bao
Jul 7, 2017·Chemistry : a European Journal·Liang GeHongli Bao
May 17, 2018·Chemistry, an Asian Journal·Liang GeHongli Bao
May 23, 2019·Angewandte Chemie·Dirk Leifert, Armido Studer

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