Copper-Catalyzed sp(3) C-H Aminative Cyclization of 2-Alkyl-N-arylbenzamides: An Approach for the Synthesis of N-Aryl-isoindolinones

Organic Letters
Kanako Nozawa-KumadaYoshinori Kondo

Abstract

The synthesis of isoindolinones via copper-catalyzed sp(3) C-H functionalization of 2-alkyl-N-substituted benzamides is described. This process does not require the preparation of halogenated substitutes, expensive transition metals, or toxic Sn or CO gas. This method provides an efficient approach to generate various functionalized isoindolinones.

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Citations

Aug 10, 2016·The Journal of Organic Chemistry·Chiaki YamamotoMasahiro Miura
Jan 14, 2017·The Journal of Organic Chemistry·Robin B BedfordCarolina Méndez-Gálvez
Jun 6, 2019·Beilstein Journal of Organic Chemistry·Edorta Martínez de MarigortaFrancisco Palacios

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