Copper-catalyzed synthesis of esters from ketones. Alkyl group as a leaving group

Organic Letters
Yuji NakataniShinichi Saito

Abstract

The conversion of ketones to esters has been achieved through the use of Cu catalyst and tetrabutylammonium nitrite. This reaction involves the activation of the less activated C-C bond, and the alkyl group is removed as a leaving group. Various isopropyl ketones are found to be good substrates for this reaction.

References

Aug 16, 2002·Chemistry : a European Journal·Chul-Ho JunDae-Yon Lee
Nov 21, 2002·Journal of the American Chemical Society·Masahiro MurakamiYoshihiko Ito
Jan 23, 2003·Journal of the American Chemical Society·Suzanne C Bart, Paul J Chirik
May 29, 2003·Journal of the American Chemical Society·Tomohiro Shimada, Yoshinori Yamamoto
May 8, 2004·Science·Elitza I TochevaMichael E P Murphy
Sep 9, 2004·Chemical Reviews·G-J ten BrinkR A Sheldon
Oct 28, 2004·Journal of the American Chemical Society·Yoshiaki NakaoTamejiro Hiyama
Dec 14, 2004·Chemical Society Reviews·Chul-Ho Jun
Jun 22, 2006·Journal of the American Chemical Society·Mamoru TobisuNaoto Chatani
Aug 31, 2006·Journal of the American Chemical Society·Yoichiro KuninobuKazuhiko Takai
Jul 12, 2007·Chemical Reviews·Michael RubinVladimir Gevorgyan

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Citations

Mar 26, 2009·Chemical Communications : Chem Comm·Masahiro OishiHideki Amii
May 21, 2019·Chemistry, an Asian Journal·Vaibhav SableAnant R Kapdi
Jan 29, 2013·The Journal of Organic Chemistry·Narsimha Mamidi, Debasis Manna

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