PMID: 11903959Mar 21, 2002Paper

Copper, ceruloplasmin and superoxide dismutase (SOD1) in patients with Down's syndrome

Pharmacology & Toxicology
G TórsdóttirT Jóhannesson

Abstract

The aim of this study was primarily to investigate whether similar signs of copper dyshomeostasis occur in dementia with age in Down's syndrome as previously found in Alzheimer's disease. Copper was accordingly determined in plasma, ceruloplasmin concentration in serum, ceruloplasmin oxidative activity and ceruloplasmin specific oxidative activity (activity related to mass) in serum, and superoxide dismutase (SOD1) in erythrocytes in 35 (27 males, 8 females) 18-53 years old (average 37 years) patients with Down's syndrome (Down's patients) and their age- and gender-matched controls. SOD1 activity was on an average almost 50% higher in the patients than in their controls but the evidence of a causal relationship between increased SOD1 activity and Down's syndrome appears at best equivocal. Copper and ceruloplasmin levels and ceruloplasmin activities were similar in the patients and their controls. Ceruloplasmin and copper levels increased significantly with age in the patients but not in the controls. Ceruloplasmin activities or SOD1 activity did not change significantly with age, neither in the patients nor in the controls as whole groups. When SOD1 activity and ceruloplasmin activities of the oldest in the patients group (40 y...Continue Reading

Citations

Nov 5, 2005·Brain Research. Brain Research Reviews·Vadim VassilievPaolo Zatta
Nov 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thomas A BayerGerd Multhaup
Sep 21, 2011·Proteome Science·Wendy E HeywoodNeil D Avent
Nov 13, 2012·Neuropsychiatric Disease and Treatment·Jakob KristinssonTorkell Jóhannesson
Nov 19, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Bin YuShi-He Shao
Feb 1, 2005·Basic & Clinical Pharmacology & Toxicology·Gudlaug TórsdóttirTorkell Jóhannesson
Oct 26, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Rodrigo GuzmánAngela Casado
Nov 2, 2013·Neurobiology of Aging·Katherine M DaviesKay L Double
Oct 3, 2007·Mental Retardation and Developmental Disabilities Research Reviews·Ahmad SalehiWilliam C Mobley
Jan 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gennady ErmakKelvin J A Davies
Aug 5, 2004·Journal of Neuropathology and Experimental Neurology·Robert E Mrak, W Sue T Griffin
Sep 21, 2010·Journal of the Neurological Sciences·Gudlaug TorsdottirTorkell Jóhannesson

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