Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration

Neurology
Neeraj KumarJ Eric Ahlskog

Abstract

Copper deficiency in ruminants is known to cause an ataxic myelopathy. Copper deficiency as a cause of progressive myelopathy in adults is underrecognized. To describe the clinical, biochemical, electrophysiologic, and imaging characteristics in 13 patients with myelopathy associated with copper deficiency. The records of patients with a copper deficiency-associated myelopathy were reviewed. Clinical characteristics, laboratory investigations, and responses to therapeutic intervention were summarized. Thirteen such patients were found, 11 of them in a 15-month period. All patients presented with prominent gait difficulty, reflecting a sensory ataxia due to dorsal column dysfunction and lower limb spasticity. All patients had polyneuropathy. A high or high-normal serum zinc level was seen in 7 of the 11 patients for whom this information was available. Somatosensory evoked potential studies done in eight patients showed impaired conduction in central proprioceptive pathways. Dorsal column signal change on spine MRI was present in three patients. An initial clue to the diagnosis was a very low ceruloplasmin level; further tests of copper metabolism excluded Wilson disease. The cause remained unexplained in most patients. Oral cop...Continue Reading

Citations

Feb 16, 2008·Der Nervenarzt·A Jung, M Marziniak
Nov 2, 2005·Neuroradiology·Neeraj KumarJohn D Port
Mar 17, 2010·Journal of Neurology·Stephan R Jaiser, Gavin P Winston
Jan 29, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ali Asghar MoshtaghieMohsen Ani
Dec 16, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Fangyu PengOtto Muzik
Sep 16, 2010·Current Treatment Options in Neurology·Stacy A Rudnicki
Oct 20, 2009·The Cerebellum·Jacob A Lyons, Joseph R Prohaska
Dec 31, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Neeraj KumarJohn B Gross
Feb 6, 2009·Nature Clinical Practice. Neurology·Rebecca I SpainEduardo A De Sousa
Sep 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michelle L SchliefJonathan D Gitlin
Jan 30, 2007·Journal of Computer Assisted Tomography·John W Allred, Joseph M Aulino
Sep 6, 2008·Journal of Clinical Neuromuscular Disease·Praful KelkarSuraj A Muley
Jun 3, 2010·Journal of Clinical Neuromuscular Disease·Yaohui Chai, Tulio E Bertorini
Feb 16, 2011·Journal of Clinical Neuromuscular Disease·Calin I ProdanLinda D Cowan
Jul 4, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J LirongZ Chunjiu
Apr 29, 2006·Journal of Clinical Pathology·P J TwomeyA S Wierzbicki
Aug 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·C I ProdanS E Lind
Apr 7, 2005·Postgraduate Medical Journal·S SanghaM M Wolfe
Mar 21, 2007·Annual Review of Neuroscience·Erik Madsen, Jonathan D Gitlin
Sep 13, 2012·Journal of Obesity·Danielle A BeckerSteven L Galetta
Jul 20, 2012·Continuum : Lifelong Learning in Neurology·Brent P Goodman
Nov 2, 2006·Internal Medicine·Yasuharu TokudaGerald H Stein
Jun 6, 2009·Future Microbiology·Elena R VirtueLin-Fa Wang
Feb 13, 2014·Clinical Neuroradiology·S WeidauerE Hattingen
Aug 31, 2014·Current Neurology and Neuroscience Reports·José M Ferro, Sofia Oliveira
Dec 8, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Irene Y L TanTrevor A Gray
Sep 23, 2014·Neurology India·Geysu Karlikaya, Dilaver Kaya
Sep 6, 2007·Leukemia & Lymphoma·Sarah E ManglesBarbara J Bain
May 1, 2009·Expert Review of Neurotherapeutics·Joseph F QuinnTeri L Wadsworth
Jun 18, 2010·The American Journal of the Medical Sciences·Lawrence B Afrin
Apr 15, 2009·The American Journal of the Medical Sciences·Calin I ProdanStuart E Lind
May 7, 2013·Neurologic Clinics·Richard J Barohn, Anthony A Amato
Apr 9, 2013·Journal of the Neurological Sciences·Rajesh VermaHardeep Singh Malhotra
Feb 6, 2013·La Revue de médecine interne·Y S OliveiraJ-R Nzenze
Nov 29, 2012·Neurologic Clinics·Robert N Schwendimann
Jul 10, 2013·Semergen·K M Martinez EstradaL García Méndez
May 23, 2012·Gastroenterología y hepatología·Jesús Lozano HerreroMaría Isabel López Espín
Oct 1, 2011·Journal of Critical Care·Andrew DuncanJohn Kinsella

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.