Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Joshua W Pyatskowit, Joseph Prohaska

Abstract

Iron homeostasis depends on adequate dietary copper but the mechanisms are unknown. Mice (Mus musculus) and rat (Rattus norvegicus) offspring were compared to determine the effect of dietary copper deficiency (Cu-) on iron status of plasma, liver, brain and intestine. Holtzman rat and Hsd:ICR (CD-1) outbred albino mouse dams were fed a Cu- diet and drank deionized water or Cu supplemented water. Offspring were sampled at time points between postnatal ages 13 and 32. Cu- rat and mouse pups were both anemic, but only rat pups had lower plasma and brain iron levels. Plasma iron was lower throughout the suckling period in Cu- rats but not Cu- mice. Cu- mice derived from dams restricted of Cu only during lactation were also severely anemic without hypoferremia. Intestinal metal analysis confirmed that Cu- pups had major reductions in intestinal concentration of Cu, increased Fe, and normal Zn. However, whole mouse (less the intestine) analysis demonstrated normal content of Fe indicating that the limitation in iron transport by intestinal hephaestin had no consequence to total iron reserves of the mouse. Further research will be needed to determine the reason Cu- mice were anemic since the "ferroxidase" hypothesis does not explain t...Continue Reading

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Citations

Oct 20, 2009·The Cerebellum·Jacob A Lyons, Joseph R Prohaska
Feb 19, 2010·The Journal of Nutrition·Supak JenkitkasemwongMitchell D Knutson
Jul 6, 2014·Annual Review of Nutrition·Sukru Gulec, James F Collins
Feb 2, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Joseph R Prohaska, Margaret Broderius
Apr 14, 2010·Nutrition Reviews·James F CollinsMitchell D Knutson
Oct 23, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ekaterina IlyechovaLudmila Puchkova
Feb 23, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Margaret BroderiusJoseph R Prohaska
Mar 6, 2012·Biochimica Et Biophysica Acta·Tracy NevittDennis J Thiele
Jul 23, 2016·Biological Trace Element Research·Denis M Medeiros
Sep 23, 2008·The Journal of Nutrition·Joshua W Pyatskowit, Joseph R Prohaska
Sep 11, 2019·The Journal of Nutrition·Xiaoyu WangJames F Collins
Jul 31, 2020·Mini Reviews in Medicinal Chemistry·Mahsa MalekahmadiMajid Ghayour Mobarhan

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