Copper differentially regulates the activity and degradation of yeast Mac1 transcription factor.

The Journal of Biological Chemistry
Z ZhuD J Thiele

Abstract

Copper is an essential metal ion that is toxic when accumulated to high intracellular concentrations. The yeast Mac1 protein is a copper-sensing transcription factor that is essential for both the activation and inactivation of genes required for high affinity copper ion transport. Here we demonstrate that in response to low copper ion concentrations Mac1 protein is rendered inactive for copper transporter gene transcription. Under high copper ion concentrations Mac1 is degraded in a rapid, copper-specific manner. This degradation is critical to prevent copper toxicity that would otherwise result from sustained expression of the copper transport genes. These results demonstrate that nutritional and toxic copper concentrations elicit distinct fates for the Mac1 copper-sensing transcription factor and establish a new mechanism by which trace metals regulate gene expression.

References

Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·E B GrallaJ S Valentine
Jul 1, 1988·Molecular and Cellular Biology·D J Thiele
Apr 1, 1984·The Biochemical Journal·B Halliwell, J M Gutteridge
Jan 6, 1995·The Journal of Biological Chemistry·R Hassett, D J Kosman
May 14, 1996·Biochemistry·W S WillettC S Craik
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·J A Graden, D R Winge

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Citations

Dec 22, 1999·Trends in Microbiology·S Labbé, D J Thiele
Sep 29, 2012·Genome Biology and Evolution·Andrea Hodgins-DavisJeffrey P Townsend
Feb 12, 2013·Eukaryotic Cell·Jude BeaudoinSimon Labbé
Nov 10, 2005·Eukaryotic Cell·Greg KellerDennis R Winge
Feb 10, 2006·Eukaryotic Cell·Jude Beaudoin, Simon Labbé
Jan 16, 2007·Journal of Bacteriology·Mihaela PruteanuTania A Baker
Jan 27, 2009·Journal of Bacteriology·Shashi ChillappagariMohamed A Marahiel
May 5, 2012·PloS One·Raphael IoannoniSimon Labbe
Sep 21, 2007·Biochimica Et Biophysica Acta·Faiza Hussain, Pernilla Wittung-Stafshede
Aug 9, 2011·Molecular Microbiology·Chen DingDennis J Thiele
May 3, 2008·Microbiology·Alexandra WoodacreAnnette M Cashmore
Jun 28, 2003·FEMS Microbiology Reviews·Marc Solioz, Jivko V Stoyanov
Jul 22, 2006·Biochimica Et Biophysica Acta·Natasha Grotz, Mary Lou Guerinot
Jul 27, 2002·Annual Review of Microbiology·Anthony Van HoJerry Kaplan
Jun 22, 2016·Current Opinion in Microbiology·Elizabeth R Ballou, Duncan Wilson
Jul 14, 2007·The Journal of Biological Chemistry·Devis SinaniJaekwon Lee
Aug 3, 2000·The Journal of Biological Chemistry·C GrossD R Winge
Dec 14, 1999·The Journal of Biological Chemistry·S LabbéD J Thiele
Feb 13, 1999·The Journal of Biological Chemistry·D Radisky, J Kaplan
May 23, 1998·Molecular and Cellular Biology·M M PeñaD J Thiele
Oct 27, 2017·FEMS Microbiology Reviews·Franziska GerwienSascha Brunke
Feb 20, 2017·Current Genetics·Yoko KusuyaHiroki Takahashi
Mar 16, 2017·Frontiers in Molecular Biosciences·Lisa-Marie BittnerFranz Narberhaus

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