Copper dysfunction in Alzheimer's disease: from meta-analysis of biochemical studies to new insight into genetics

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
R Squitti

Abstract

The involvement of body copper metabolism in the development of Alzheimer's disease (AD) - the most common form of dementia - is a deeply investigated issue in recent years. Copper is essential for life, but in excess it can be toxic. Recently, it has been hypothesized that copper toxicity may be a contributory factor in the etiology of the neurodegenerative disease AD. Studies on copper evaluation in AD vs. healthy controls collected in the latest 30 years and merged in a meta-analysis demonstrate that serum copper is slightly increased in AD. A specific form of copper, the copper non-bound to ceruloplasmin, or 'free' copper, seems to best characterize this increase in copper in AD patients. Clinical studies from us and other groups have demonstrated that free copper is associated with the typical deficits of AD, incipient AD and mild cognitive impairment, and specific cerebrospinal markers. Moreover, very recent data addressing molecular processes underlying copper dysfunction in AD have indicated that genetic variations of K832R and R952K Single Nucleotide Polymorphisms (SNPs) of the Wilson's disease gene ATP7B are associated also with sporadic AD. Specifically, ATP7B encodes for the protein ATPase 7B which controls free cop...Continue Reading

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Citations

Sep 7, 2012·Rejuvenation Research·Rosanna SquittiPaolo Maria Rossini
Jan 18, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Amit PalRajendra Prasad
Jul 19, 2013·BioMed Research International·Nan HuLan Tan
Nov 21, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Rosanna SquittiRenato Polimanti
May 15, 2013·Neuroscience Letters·Yasuha NodaKengo Uemura
Apr 30, 2013·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Khaled K Al-QattanMohamed H Mansour
Jul 4, 2012·Biochemical and Biophysical Research Communications·Bo ZengShang-Zhong Xu
Mar 20, 2015·Chemical Reviews·Jessica Nasica-LabouzePhilippe Derreumaux
Nov 30, 2013·International Journal of Alzheimer's Disease·Nathalie ArnalCarlos A Marra
Nov 15, 2013·International Journal of Alzheimer's Disease·Alan RembachBlaine R Roberts
Aug 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Itender SinghRashid Deane
Aug 9, 2016·Metallomics : Integrated Biometal Science·R SquittiL Rossi
Mar 21, 2019·Frontiers in Chemistry·Cezary GrochowskiRyszard Maciejewski
May 31, 2018·Journal of Alzheimer's Disease : JAD·Rosanna SquittiRoberta Ghidoni
May 21, 2017·Journal of Alzheimer's Disease : JAD·Mengxi Tang, Changiz Taghibiglou

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