Copper exposure association with prevalence of non-alcoholic fatty liver disease and insulin resistance among US adults (NHANES 2011-2014).

Ecotoxicology and Environmental Safety
Chen ChenLiang Sun

Abstract

Excessive copper (Cu) has risky effect on insulin resistance (IR), oxidative stress and inflammation. Instead, some studies reported serum Cu to be protective for non-alcoholic fatty liver disease (NAFLD). The aim of this study was to reevaluate the evidence for a potential risky correlation of serum Cu to NAFLD in large-scale and non-institutionalized American subjects. A cross-sectional study of 3211 subjects was from the National Health and Nutrition Examination Survey (NHANES). Logistic regression and cubic spline-based curve-fitting analyses were used to estimate the independent risky effect of Cu to hepatic steatosis index (HSI), US fatty liver index (USFLI) and NAFLD and their dose-effect relationship. Moreover, this association was analyzed in stratification of HOMA-IR, Metabolic syndrome (MetS) and severity of NAFLD, besides age and gender. The average level of serum Cu was 18.67 μmol/L and the prevalence of NAFLD was 54.53% and 32.60%, respectively defined by HSI and USFLI. Generally, the level of Cu was higher in females than males. Serum Cu was positively associated with higher HSI, USFLI index and risk of NAFLD. In fully adjusted models, compared with the lowest quartile, the risk of NAFLD increased 97% in the high...Continue Reading

References

Nov 30, 1993·Biochemical and Biophysical Research Communications·Y YamaguchiJ D Gitlin
Mar 19, 2003·The New England Journal of Medicine·Jennifer HaysUNKNOWN Women's Health Initiative Investigators
Oct 23, 2004·International Journal of Cancer. Journal International Du Cancer·Baojun ChangMasayasu Inoue
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Arun J Sanyal
Dec 20, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Constance E Ruhl, James E Everhart
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul AnguloChristopher P Day
Jan 30, 2009·Veterinary Pathology·R SmedleyW Rumbeiha
Aug 18, 2009·Biological Trace Element Research·Miguel ArredondoMagdalena Araya
Sep 22, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Jeong-Hoon LeeHyo-Suk Lee
Apr 22, 2010·The American Journal of Gastroenterology·Elmar AignerChristian Datz
Jan 5, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J ArnaudUNKNOWN European Collaborative Group of the IMMIDIET Project
Feb 24, 2011·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Daniel López de RomañaMagdalena Araya
Nov 17, 2012·Journal of Pediatric Gastroenterology and Nutrition·Valerio NobiliRosanna Squitti
May 1, 2013·International Journal of Medical Sciences·Chih-Hung GuoWang-Sheng Ko
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jun 25, 2014·The American Journal of Gastroenterology·Peter J MeffertHenry Völzke
Nov 8, 2014·Alimentary Pharmacology & Therapeutics·C E Ruhl, J E Everhart
Jun 10, 2015·JAMA : the Journal of the American Medical Association·Mary E Rinella
Jul 29, 2015·Journal of Agricultural and Food Chemistry·Eleonora Brillo, Gian Carlo Di Renzo
Apr 3, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A LonardoG Targher
Apr 7, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·G H O RochaP Nishiyama
Apr 12, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver (EASL)UNKNOWN European Association for the Study of Obesity (EASO)
Dec 3, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Albert Friedrich StättermayerPeter Ferenci
Mar 25, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Elena BuzzettiEmmanuel Tsochatzis
Dec 15, 2017·European Journal of Clinical Nutrition·Peter L RippbergerJohn A Batsis
Mar 7, 2018·Oncotarget·Cristiana PorcuClara Balsano
Aug 21, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kaveh HajifathalianArthur J McCullough
Dec 27, 2018·Cellular and Molecular Gastroenterology and Hepatology·Claudia EinerHans Zischka
Mar 30, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Donghee KimAijaz Ahmed
Jul 16, 2019·Environmental Toxicology and Pharmacology·Thelma Ameh, Christie M Sayes
Jul 23, 2019·Alimentary Pharmacology & Therapeutics·Donghee KimAijaz Ahmed
Oct 12, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yanqi LanLi Wang

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