Mar 24, 2011

Copper, gold and silver compounds as potential new anti-tumor metallodrugs

Future Medicinal Chemistry
Shiow Jin TanKok Hwa Lim

Abstract

Although platinum-based drugs such as cisplatin are powerful anticancer agents, they have undesirable side effects and are effective against only a few kinds of cancers. There is, therefore, a need for new drugs with an improved spectrum of efficacy and lower toxicity. Complexes of copper, gold and silver (coinage metals) are potential candidates to fulfill this need. The development of anticancer drugs based on these metals is currently a very active field. Considerable effort has also been put into elucidating the mechanisms of action of these complexes and optimizing their bioactivity through structural modification. In this review, we highlight recent developments in the design of coinage metal complexes with anti-tumor activity and discuss the emerging importance of quantitative structure-activity relationship methods in the study of anticancer metal complexes. Future work in this field, including likely coinage metal complexes that will attract attention, are proposed.

  • References120
  • Citations17
  • References120
  • Citations17

Mentioned in this Paper

Antineoplastic Agents
Complex (molecular entity)
Neoplasms
Silver Compounds, Inorganic
Leishmaniasis, Cutaneous
Copper
Quantitative Structure Property Relationship
Silver Compounds
Malignant Neoplasms
Gold Compounds

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