Copper (II) and/or arsenite-induced oxidative stress cascades apoptosis and autophagy in the skeletal muscles of chicken

Chemosphere
Yu WangMingwei Xing

Abstract

Arsenic (As) is a ubiquitous environmental toxin and robust inducer of oxidative stress (OxS). Copper (Cu) is an essential microelement, which participates in OxS as a cofactor for certain enzymes, with narrow optimal range between essential and toxic concentrations. However, their effects are rarely studied in chicken skeletal muscles, which have soaring per capita consumption andare susceptible to oxidative damage. In the present study, we demonstrated that the administration of copper sulfate (300 mg kg-1) or arsenite (30 mg kg-1) individually or their co-administration leads to varying degrees of OxS in the skeletal muscles of chickens. Corresponding to the protein expression pattern, the mRNA levels of caspase, B-cell lymphoma-2 (Bcl-2) families, and autophagy-related genes were also compromised in the experimental groups, indicating the involvement of both apoptotic and autophagic cell death. Additionally, rampant mitochondrial fission caused the vicious cycle between imbalanced mitochondrial dynamics and OxS, thus tethering intracellular homeostasis. The abovementioned muscle damage and index anomalies were time dependent, and more deteriorated effects were observed in Cu2+ and arsenite co-administered groups than those ...Continue Reading

Citations

Dec 6, 2018·Metallomics : Integrated Biometal Science·Yu WangMingwei Xing
Jun 22, 2019·Environmental Science and Pollution Research International·Xiangqi TengRuili Zhang
Jun 21, 2019·Biological Trace Element Research·Jianwen XuZiwei Zhang
Sep 4, 2020·Biological & Pharmaceutical Bulletin·Min Cheol PyoKwang-Won Lee
Sep 27, 2018·Environmental Science and Pollution Research International·Hongjing ZhaoMingwei Xing
Oct 28, 2019·Metallomics : Integrated Biometal Science·Kou-Kou TangRui-Feng Fan
Jun 16, 2019·Environmental Science and Pollution Research International·Kou-Kou TangRui-Feng Fan
Feb 23, 2020·Biological Trace Element Research·Jianying GuoZhaoxin Tang
Jul 21, 2020·Autophagy·Sophie TesseraudIban Seiliez
Nov 24, 2020·Metallomics : Integrated Biometal Science·Rui-Feng FanZhen-Yong Wang
Aug 14, 2019·Ecotoxicology and Environmental Safety·Chaoqun WangZhengkai Wei
Sep 24, 2019·Journal of Hazardous Materials·Yu WangMingwei Xing
Feb 5, 2021·Environmental Pollution·Zijiang YangShiwen Xu
Mar 26, 2021·Environmental Science and Pollution Research International·Zhang YimingLi Shu

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