Copper in medicine: homeostasis, chelation therapy and antitumor drug design

Current Medicinal Chemistry
Tuo Wang, Zijian Guo

Abstract

As one of the most important essential transition metals, copper is involved in a variety of biological processes such as embryo development, connective tissue formation, temperature control and nerve cell function. It is also related to severe diseases such as Wilson's and Menkes diseases and some neurological disorders. Novel components of copper homeostasis include copper-transporting P-type ATPases, Menkes and Wilson proteins, and copper chaperones in humans have been identified and characterized at the molecular level. These findings have paved the way towards better understanding of the role of copper deficiency or copper toxicity in physiological and pathological conditions. Therefore, organic compounds that can interfere with copper homeostasis may find therapeutic application in copper-dependent diseases. The antitumor activity of copper complexes was reported several decades ago, and many new complexes have demonstrated great antitumor potential. Copper complexes may have relatively lower side effects than platinum-based drugs, and are suggested to be able to overcome inherited or acquired resistance of cisplatin. In this overview, the most recent advances in copper homeostasis, copper-related chelation therapy and de...Continue Reading

Citations

Dec 23, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Christian R KowolBernhard K Keppler
May 30, 2008·Pharmaceutical Research·Christopher D HeinDong Wang
Oct 10, 2013·Chemical Reviews·Carlo SantiniCristina Marzano
Mar 24, 2011·Future Medicinal Chemistry·Shiow Jin TanKok Hwa Lim
Dec 18, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Odile DiouNicolas Tsapis
Aug 15, 2014·Biological Trace Element Research·Lorena BeccoBeatriz Garat
May 28, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ying LiYuhua Mei
Feb 5, 2016·Biochimica Et Biophysica Acta·Danuta S KalinowskiDes R Richardson
Jul 25, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marc PretzeConstantin Mamat
Nov 26, 2010·Mass Spectrometry Reviews·Robert Jirásko, Michal Holčapek
Aug 19, 2015·Bioconjugate Chemistry·Samad AhadianAli Khademhosseini
Jul 25, 2009·Medicinal Research Reviews·Francesco TisatoCarlo Santini
Jul 7, 2010·Chemico-biological Interactions·María Eugenia LetelierPaula Aracena-Parks
Dec 22, 2011·Metallomics : Integrated Biometal Science·Clare Duncan, Anthony R White
Sep 17, 2016·Scientific Reports·Anna Maria SantoroDanilo Milardi
Jun 19, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Urszula K KomarnickaMałgorzata Jeżowska-Bojczuk
Mar 5, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry· SaswatiRupam Dinda
Nov 14, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Agnieszka KadejTeresa Kowalik-Jankowska
Apr 9, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Laura Acosta-RuedaEnrique García-España
Oct 27, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Qingming WangXueqi Fu
Oct 27, 2017·Scientific Reports·Valentina GandinCristina Marzano
Dec 29, 2010·Analytical and Bioanalytical Chemistry·Roberta Seraglia, Pietro Traldi
Nov 14, 2012·Chemical Society Reviews·Wukun Liu, Ronald Gust
Aug 13, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·David AguilàSantiago Alvarez
Feb 19, 2013·Chemical Communications : Chem Comm·Anupa A KumbharKatherine J Franz
Aug 7, 2014·Metallomics : Integrated Biometal Science·Rosa F BrissosPatrick Gamez
Sep 22, 2017·Metallomics : Integrated Biometal Science·Valentina OliveriGraziella Vecchio
May 21, 2010·Rapid Communications in Mass Spectrometry : RCM·Francesco TisatoPietro Traldi
Mar 15, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Qiu-Yun ChenJing Gao
Sep 15, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Daniele SannaEugenio Garribba

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