Copper mediated C-H amination with oximes: en route to primary anilines

Chemical Science
Lin-Lin XuJin-Quan Yu

Abstract

Here we report an efficient Cu(i)-mediated C-H amination reaction with oximes as amino donors to introduce NH2 groups directly. Various strongly coordinating heterocycles including quinoline, pyrimidine, pyrazine, pyrazole and triazole were tolerated well. The potential utility was further demonstrated in a late-stage modification of telmisartan (an antagonist for the angiotensin II receptor).

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Citations

Feb 14, 2019·Organic & Biomolecular Chemistry·Fangpeng HuGuosheng Huang
Jun 4, 2019·Organic & Biomolecular Chemistry·Qiumin KeXiangmei Wu
Oct 19, 2019·Angewandte Chemie·Jin-Feng YuJin-Quan Yu
Jan 10, 2020·Chemical Communications : Chem Comm·Shang-Zheng SunHui-Xiong Dai
May 28, 2020·Organic & Biomolecular Chemistry·Huiyong YangWanmei Li
May 28, 2020·Organic & Biomolecular Chemistry·Fang-Peng HuGuo-Sheng Huang
Jul 24, 2021·Chemical Communications : Chem Comm·Wensen OuyangXianwei Li
Jul 28, 2021·The Journal of Organic Chemistry·Wei-Hao RaoGuo-Dong Zou
Aug 14, 2021·Beilstein Journal of Organic Chemistry·Renato L CarvalhoEufrânio N da Silva Júnior
Apr 5, 2019·Organic Letters·Kengo HyodoKingo Uchida
Jul 17, 2019·Organic Letters·Xing WangHui-Xiong Dai
Oct 23, 2018·Journal of the American Chemical Society·Hyunwoo KimSukbok Chang
Oct 28, 2021·Organic Letters·Tai-Jin ChengHui-Xiong Dai
Dec 30, 2021·Organic Letters·Zheng-Hai Wang, Dong-Hui Wang

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Methods Mentioned

BETA
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