Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridines

Chemical Communications : Chem Comm
Qiaodong WenYanguang Wang

Abstract

A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2-a]pyridines from 2-aminopyridines, acetophenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide from benzyl cyanide, a copper-mediated Ortoleva-King reaction, and a copper-catalyzed cyanation.

References

Dec 4, 1998·Journal of Medicinal Chemistry·A GueiffierJ P Chapat
Feb 6, 2004·Journal of Medicinal Chemistry·Ajay N Jain
Dec 24, 2005·Chemical Communications : Chem Comm·Luciano Menini, Elena V Gusevskaya
May 25, 2006·Journal of the American Chemical Society·Xiao ChenJin-Quan Yu
Jan 27, 2007·The Journal of Organic Chemistry·Erin F Dimauro, Joseph M Kennedy
Oct 21, 2009·Chemical Communications : Chem Comm·Lujuan YangShannon S Stahl
Jun 8, 2011·Journal of the American Chemical Society·Olga N BurchakMaxim Y Balakirev
Jan 28, 2012·Journal of the American Chemical Society·Jinho KimSukbok Chang
Feb 23, 2012·Journal of Medicinal Chemistry·Andrés A TrabancoJosé María Cid
Aug 31, 2012·Chemical Communications : Chem Comm·Jisong JinYanguang Wang
Sep 29, 2012·Chemical Communications : Chem Comm·Chuan HeAiwen Lei
Nov 8, 2012·Angewandte Chemie·Jinho KimSukbok Chang
Nov 22, 2012·The Journal of Organic Chemistry·Hongpeng SunJingkang Shen

❮ Previous
Next ❯

Citations

Sep 24, 2016·The Journal of Organic Chemistry·Chitrakar RaviSubbarayappa Adimurthy
Mar 21, 2017·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Chitrakar Ravi, Subbarayappa Adimurthy
Aug 23, 2019·Beilstein Journal of Organic Chemistry·Gagandeep Kour ReenPratibha Sharma
Feb 13, 2021·The Journal of Organic Chemistry·Ting CuiPeipei Sun
Dec 19, 2018·The Journal of Organic Chemistry·Rashmi SemwalSubbarayappa Adimurthy
Jun 6, 2017·The Journal of Organic Chemistry·Xinju ZhuXin-Qi Hao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.