Copper-metformin ternary complexes: Thermal, photochemosensitivity and molecular docking studies

Materials Science & Engineering. C, Materials for Biological Applications
Vasantha PAnantha Lakshmi P V

Abstract

The copper(II) complexes [Cu(Cl)2(met)(o-phen)] (1), [Cu(Cl)2(met)(en)] (2) and [Cu(Cl)2(met)(opda)] (3) (met = metformin, o-phen = ortho-phenanthroline, en = ethylenediamine, opda = ortho-phenylenediamine) were synthesized and characterized by LC-MS, elemental analysis, molar conductance, thermal analysis, infrared spectra, magnetic moment, electronic spectra and XRD studies. The metal center was found in an octahedral geometry. The activation thermodynamic properties were calculated using Coats-Redfern method. Thermal decomposition processes of complexes 1, 2, 3 are non-spontaneous, i.e., the complexes are thermally stable. The positive value of Gibbs free energy of decomposition (ΔG⁎) for the Cu(II) complexes is non-spontaneous processes. UV-Visible absorption, fluorescence, and viscosity measurements have been conducted to assess the interaction of the complexes with CT DNA. The complexes showed absorption hyperchromism in its UV-Vis spectrum with DNA. The binding constants Kb from UV-Vis absorption studies were 4.6 × 105, 1.48 × 105, 2.09 × 105 M-1 for 1, 2, 3 respectively and Stern-Volmer quenching constants (Ksq) from fluorescence studies were 0.636, 0.293, 0.487 for 1, 2, 3 respectively. Finally, viscosity measurements ...Continue Reading

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