Copper-modified Ti6Al4V alloy fabricated by selective laser melting with pro-angiogenic and anti-inflammatory properties for potential guided bone regeneration applications

Materials Science & Engineering. C, Materials for Biological Applications
Xiongcheng XuJinxin Lin

Abstract

Custom-made biocompatible titanium alloy mesh can be designed to facilitate the regeneration of alveolar bone defects by supporting a protected space and inhibiting bacterial infections. Copper ions are often incorporated into titanium alloy due to their high bioactivity and outstanding antibacterial properties. However, the impacts of copper-bearing alloys on peri-implanted cell behaviors have rarely been systematically explored. In the present study, a copper-bearing alloy (Ti6Al4V-6Cu) was fabricated by selective laser melting (SLM) technology. The characterization of Ti6Al4V-6Cu alloy and its effects on the behaviors of gingival fibroblasts (HGFs), human umbilical vein endothelial cells (HUVECs), osteoblasts and macrophages were evaluated and compared with Ti6Al4V. The diffraction peaks of the Ti2Cu intermetallic phase were observed in the Ti6Al4V-6Cu alloy. Adding Cu enhanced the release of Ti and Al ions. The chemical state of Cu in the Ti6Al4V-6Cu alloy may exist predominantly in Cu2O or TiCuOx. Ti6Al4V-6Cu did not affect the attachment of HGFs or the osteogenic activity of osteoblasts. Furthermore, it inhibited the activation, proliferation, and pro-inflammatory cytokine secretion of macrophages and upregulated angiogen...Continue Reading

Citations

Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Li LeiIlwoo Seok
Mar 7, 2021·International Journal of Molecular Sciences·Anne BernhardtMichael Gelinsky
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Zhong WangRuiqiang Hang
May 27, 2021·Advanced Healthcare Materials·Monika ŠalandováLidy E Fratila-Apachitei
Jun 8, 2021·Journal of Orthopaedic Translation·Yufeng WangQingqiang Yao

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