Copper-Promoted Desulfitative N-Arylation of Sulfonamides and Sulfoximines with Sodium Arylsulfinates

The Journal of Organic Chemistry
Yangji JiangDelie An

Abstract

A general and direct N-arylation of sulfonamides and NH-sulfoximines by sodium arylsulfinates through a desulfitative pathway was herein demonstrated. The reaction proceeded with catalytic loadings of Cu(II)-catalysts without any external ligands. And the novel arylation protocol featured for high efficiency (up to 93% yields) and good substituent tolerance (up to 53 examples). Moreover, a plausible reaction mechanism was also discussed.

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Citations

Jun 13, 2018·Royal Society Open Science·Xiaojun LuoHuoji Chen
Apr 3, 2021·International Journal of Biological Macromolecules·Yasin OroojiMahmood Tajbakhsh
Apr 3, 2019·Organic Letters·Alexander Wimmer, Burkhard König
Aug 1, 2018·The Journal of Organic Chemistry·Qingjing YangFuk Yee Kwong
Sep 15, 2021·Chemistry : a European Journal·Michael AndresiniRenzo Luisi

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