Copper pumping ATPases: common concepts in bacteria and man

FEBS Letters
M SoliozR Krapf

Abstract

Recently, four genes encoding putative copper pumping ATPases have been cloned from widely different sources: two genes from Enterococcus hirae that are involved in copper metabolism and two human genes that are defective in the copper-related Wilson and Menkes disease. The predicted gene products are P-type ATPases. They exhibit extensive sequence similarity and appear to be members of a new class of ATP driven copper pumps involved in the regulation of cellular copper.

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Related Concepts

DNA-dependent ATPase
Copper
Hepatic Form of Wilson Disease
Menkes Kinky Hair Syndrome
Enterococcus
Protein Folding, Globular
ATP7A
ENECOPPUMP
HSU03464

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