Copper(ii) complexes with 2,2':6',2''-terpyridine, 2,6-di(thiazol-2-yl)pyridine and 2,6-di(pyrazin-2-yl)pyridine substituted with quinolines. Synthesis, structure, antiproliferative activity, and catalytic activity in the oxidation of alkanes and alcohols with peroxides

Dalton Transactions : an International Journal of Inorganic Chemistry
Katarzyna ChorobaGeorgiy B Shul'pin

Abstract

A series of 2,2':6',2''-terpyridine (terpy), 2,6-di(thiazol-2-yl)pyridine (dtpy) and 2,6-di(pyrazin-2-yl)pyridine (dppy) derivatives with n-quinolyl substituents (n = 2 and 4) was used to synthesize five-coordinate complexes [CuCl2(n-quinolyl-terpy)] (1-2), [CuCl2(n-quinolyl-dtpy)] (3-4) and [CuCl2(n-quinolyl-dppy)] (5-6), respectively. The main emphasis of the research was to investigate the impact of the triimine skeleton (terpy, dtpy and dppy) and n-quinolyl pendant substituent on the antiproliferative and catalytic properties of 1-6. The obtained Cu(ii) compounds were studied as antiproliferative agents against human colorectal (HCT116) and ovarian (A2780) carcinoma, and they were used as catalysts for the oxidation of alkanes and alcohols with peroxides under mild conditions. The kinetic characteristics of the oxidizing species generated by the catalytic system Cu(ii) complex-H2O2 in CH3CN were obtained from the dependence of the alkane oxidation rate on its initial concentration. A model of competitive interaction of hydroxyl radicals with CH3CN and RH in the catalyst cavity has been proposed which is based on the simultaneous study of kinetics and selectivity in alkane oxidations.

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Citations

Aug 26, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·João Franco MachadoTânia S Morais
Mar 27, 2020·Chembiochem : a European Journal of Chemical Biology·Jordi GrauPatrick Gamez
Jan 21, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Diogo SequeiraAlexandra R Fernandes
Jan 22, 2020·European Journal of Medicinal Chemistry·Katarzyna MalarzAnna Mrozek-Wilczkiewicz
Jan 9, 2020·ACS Combinatorial Science·Nazanin KordestaniOlivier Blacque

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Methods Mentioned

BETA
X-ray
fluorescence microscopy
xenografts

Software Mentioned

GraphPad
SHELXL97
NIS Elements Basic
CrysAlis Pro
MassLynx
Attune Cytometric
SHELXS97
GraphPad Prism

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