Copper(II)-Mediated [11 C]Cyanation of Arylboronic Acids and Arylstannanes

Organic Letters
Katarina J MakaravagePeter J H Scott

Abstract

A copper-mediated method for the transformation of diverse arylboron compounds and arylstannanes to aryl-[11C]-nitriles is reported. This method is operationally simple, uses commercially available reagents, and is compatible with a wide variety of substituted aryl- and heteroaryl substrates. This method is applied to the automated synthesis of high specific activity [11C]perampanel in 10% nondecay-corrected radiochemical yield (RCY).

References

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Apr 23, 2008·Chemical Reviews·Simon M AmetameyPius August Schubiger
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Sep 1, 2016·Journal of Labelled Compounds & Radiopharmaceuticals·Zhengxing ZhangKuo-Shyan Lin
Jun 6, 2017·Chemical Communications : Chem Comm·Longle MaSteven H Liang

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Citations

Jun 5, 2018·Angewandte Chemie·Antonio Del VecchioDavide Audisio
Aug 25, 2018·Chemical Society Reviews·Thomas C WilsonVéronique Gouverneur
Oct 6, 2018·Organic & Biomolecular Chemistry·Zhouen ZhangTakamitsu Hosoya
Jan 15, 2020·Organic & Biomolecular Chemistry·Mani RamanathanShiuh-Tzung Liu

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