Coprescribing proton-pump inhibitors with nonsteroidal anti-inflammatory drugs: risks versus benefits

Journal of Pain Research
Kok Ann GweeSajita Setia

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are often coadministered with proton-pump inhibitors (PPIs) to reduce NSAID-induced gastrointestinal (GI) adverse events. This coadministration is generally regarded as safe, and is included in many of the guidelines on NSAID prescription. However, recent evidence indicates that the GI risks associated with NSAIDs can be potentiated when they are combined with PPIs. This review discusses the GI effects and complications of NSAIDs and how PPIs may potentiate these effects, options for prevention of GI side effects, and appropriate use of PPIs in combination with NSAIDs.

Citations

Jun 27, 2019·World Journal of Gastroenterology : WJG·Giovanni BrunoCarola Severi
Aug 22, 2020·Journal of Pain Research·Kok Yuen HoErnest Choy
Feb 9, 2020·Archives of Disease in Childhood. Education and Practice Edition·Rosie CloseKate Armon
Feb 7, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Anaé MontaAnne Donnet
Jul 3, 2021·Therapeutic Advances in Musculoskeletal Disease·Christian CadetUNKNOWN and The French AGRHUM Group (Association Geriatric and RHeUMatology)
Jul 3, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Dhani WijayaElfri Padolo
Aug 28, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ju Hwan KimHak Rim Kim
Sep 28, 2021·International Journal of Palliative Nursing·Gvm Chamath Fernando, Jayamangala Sampath Kondasinghe
Nov 1, 2021·Equine Veterinary Journal·Rebecca C BishopAnnette M McCoy

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