Copy number alterations of the polycomb gene BMI1 in gliomas

Acta Neuropathologica
Valtteri HäyryNina N Nupponen

Abstract

Gliomas are heterogeneous tumours that grow in an uninhibited fashion, and these brain tumour cells share numerous characteristics with neural stem cells. The BMI1 gene encodes a component of the polycomb protein complex regulating epigenetically gene activity via histone modification. It functions for instance during the development of the central nervous system and maturation of neural cells. BMI-1 protein expression is deregulated in several forms of cancer and gene amplification has been identified in mantle cell lymphomas. Since BMI1 is located at chromosome 10p, a region implicated frequently in brain tumourigenesis, we investigated the genetic status and the corresponding expression patterns of BMI1 in a series of 100 low- and high-grade primary and recurrent gliomas. Chromogenic in situ hybridisation (CISH) with probes directed against BMI1 at 10p13 and the centromere of chromosome 10 was used in the analyses. Of all gliomas, 59% demonstrated aberrant copy numbers of BMI1. Deletions of the BMI1 locus were found in most types of tumours, and in a univariate survival analysis these cases had poor prognosis. Increased copy numbers of the BMI1 locus (3-5 copies) were found in all histological types, especially in high-grade...Continue Reading

References

Oct 23, 1997·Genes, Chromosomes & Cancer·A M VoestenT J Hulsebos
Sep 12, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M GuggerD C Betticher
Oct 21, 2003·International Journal of Cancer. Journal International Du Cancer·Ronald SimonGuido Sauter
Sep 30, 2004·The Breast : Official Journal of the European Society of Mastology·Joo Heon KimJae Wha Kim
Feb 22, 2005·Neoplasia : an International Journal for Oncology Research·Roderick H J BreuerFrank M Raaphorst
May 10, 2005·International Journal of Cancer. Journal International Du Cancer·Peter RoerigPeter Lichter
Aug 18, 2005·International Journal of Hematology·Masashi SawaTomoki Naoe
Jul 11, 2006·Acta Neuropathologica·Tea BlomNina N Nupponen
Jan 2, 2007·Current Biology : CB·Virginie ClementAriel Ruiz i Altaba
Mar 17, 2007·Nature Reviews. Genetics·Mikhail Spivakov, Amanda G Fisher
Oct 16, 2007·Cancer Cell·Sophia W M BruggemanMaarten van Lohuizen
Mar 19, 2008·Neuropathology and Applied Neurobiology·V HäyryN N Nupponen

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Citations

Aug 19, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Magdalena ZakrzewskaPaweł P Liberski
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Raman P Nagarajan, Joseph F Costello
Jun 5, 2013·Neuro-oncology·Pierpaolo PeruzziJakub Godlewski
May 11, 2012·PloS One·Bart A WestermanMaarten van Lohuizen
Dec 23, 2010·Future Oncology·Andrea Piunti, Diego Pasini
Oct 22, 2013·Journal of the Neurological Sciences·Zhenyu WuYanyang Tu
Jun 7, 2014·Pharmacological Reports : PR·Marta MaleszewskaBozena Kaminska
Mar 16, 2013·Journal of Cell Communication and Signaling·Panagiotis J Vlachostergios, Christos N Papandreou
Jul 18, 2012·Cellular and Molecular Life Sciences : CMLS·Stefano Bartesaghi, Paolo Salomoni
Nov 2, 2012·Neuromolecular Medicine·Anastasia SpyropoulouAthanasios G Papavassiliou
Jan 2, 2016·Oncology Letters·Sibin Madathan KandyChetan Ghati Kasturirangan
May 12, 2009·Seminars in Cancer Biology·Raman P Nagarajan, Joseph F Costello
Oct 23, 2008·Cancer Genetics and Cytogenetics·Tea BlomNina N Nupponen
Jun 17, 2011·Journal of Cellular Biochemistry·Liangxian CaoThomas W Davis
Mar 4, 2014·Epigenomics·Francesco Crea, Lorenzo Fornaro
Feb 22, 2012·Upsala Journal of Medical Sciences·Yiwen Jiang, Lene Uhrbom
Jan 1, 2011·Cancers·Irfan A Qureshi, Mark F Mehler
Jun 14, 2014·Brain Tumor Research and Treatment·Young Zoon Kim
Jan 1, 2013·Tsitologiia·E V Semenova, M V Filatov
May 12, 2017·Cellular and Molecular Neurobiology·Mojdeh Mahdian Nasser, Parvin Mehdipour
Nov 10, 2013·Cancers·Marta Maleszewska, Bozena Kaminska
Feb 20, 2015·Molecular Cancer Therapeutics·Monal MehtaHatem E Sabaawy
Oct 6, 2010·Molecular Cancer·Francesco CreaWilliam L Farrar

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