Copy number analysis of ductal carcinoma in situ with and without recurrence

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Kylie L GorringeIan G Campbell

Abstract

Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer and a frequent mammographic finding requiring treatment. Up to 25% of DCIS can recur and half of recurrences are invasive, but there are no reliable biomarkers for recurrence. We hypothesised that copy number aberrations could predict likelihood of recurrence. We analysed a cohort of pure DCIS cases treated only with wide local excision for genome-wide copy number and loss of heterozygosity using Affymetrix OncoScan MIP arrays. Cases included those without recurrence within 7 years (n = 25) and with recurrence between 1 and 5 years after diagnosis (n = 15). Pure DCIS were broadly similar in copy number changes compared with invasive breast cancer, with the consistent exception of a greater frequency of ERBB2 amplification in DCIS. There were no significant differences in age or ER status between the cases with a recurrence vs those without. Overall, the DCIS cases with recurrence had more copy number events than the DCIS without recurrence. The increased copy number appeared non-random with several genomic regions showing an increase in frequency in recurrent cases, including 20 q gain, ERBB2 amplification and 15q loss. Copy number changes may...Continue Reading

References

May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M HarveyD C Allred
Feb 17, 2000·Journal of the National Cancer Institute·F M WaldmanB M Ljung
Jun 17, 2004·Journal of the National Cancer Institute·Gregory D Leonard, Sandra M Swain
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·E Shelley HwangFrederic M Waldman
Sep 14, 2004·Oncogene·Jerry UsaryCharles M Perou
Sep 21, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ulrike KronenwettYudi Pawitan
Nov 3, 2006·Nature Clinical Practice. Oncology·Fabrice Andre, Lajos Pusztai
Aug 7, 2008·Breast Cancer Research : BCR·Rulla M TamimiLaura C Collins
Oct 22, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yuxia GaoSong Lu
Apr 30, 2010·Journal of the National Cancer Institute·Karla KerlikowskeThea D Tlsty
May 27, 2010·Histopathology·Maria A Lopez-GarciaJorge S Reis-Filho
Aug 31, 2010·Carcinogenesis·Wook JinSeong-Jin Kim
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peter Van LooVessela N Kristensen
Jan 29, 2011·Cancer Research·Nicolai J BirkbakCharles Swanton
Apr 19, 2011·Human Pathology·E Shelley HwangFrederic M Waldman
Jun 2, 2011·Annals of Surgical Oncology·Jonathan FongG Bruce Mann
Nov 5, 2011·Breast Cancer Research and Treatment·Clint E JohnsonIan G Campbell
Aug 23, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhigang C WangUrsula A Matulonis
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Jul 31, 2013·The Lancet Oncology·John R Benson, Gordon C Wishart
Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mila DonkerNina Bijker
Sep 28, 2013·The Breast : Official Journal of the European Society of Mastology·M M BoxerB H Chua
Sep 28, 2013·Nature Genetics·Giovanni CirielloChris Sander

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Citations

Mar 25, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jia-Min B PangStephen B Fox
Mar 8, 2019·The Journal of Pathology·Tanjina KaderKylie L Gorringe
Apr 25, 2019·International Journal of Cancer. Journal International Du Cancer·Mieke R Van BockstalCarolien H M van Deurzen
Jul 10, 2019·British Journal of Cancer·Maartje van SeijenUNKNOWN PRECISION team
Oct 11, 2019·Breast Cancer Research and Treatment·Abrar I AljohaniEmad A Rakha
Nov 20, 2016·The Journal of Pathology·Anna K CasasentNicholas E Navin
Mar 10, 2016·Cancer Metastasis Reviews·Christine DesmedtJanina Kulka
Nov 8, 2017·Frontiers in Oncology·Kylie L Gorringe, Stephen B Fox
Jun 30, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Islam M MiligyEmad A Rakha
May 4, 2018·Breast Cancer Research : BCR·Tanjina KaderKylie L Gorringe
Aug 20, 2019·Breast Cancer Research and Treatment·Chieh-Yu LinRobert B West
Jun 15, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shona HendryStephen B Fox
Jul 17, 2021·Breast Cancer Research : BCR·Peipei LuRobert West
Sep 3, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mieke R Van BockstalChristine Galant

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