Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma

International Journal of Oncology
Takehiko YokoboriMasaki Mori

Abstract

FBXW7 is a tumor suppressor gene that plays a role in cell cycle regulation via Myc degradation. However, the clinical significance of FBXW7 in esophageal squamous cell carcinoma (ESCC) has not been evaluated. The purpose of this study was to assess the clinical significance of FBXW7 for prognosis in human ESCC. Real-time RT-PCR was used to examine the expression of FBXW7 to determine its clinicopathological significance in 75 cases of ESCC. Overall survival rate was calculated using the Kaplan-Meier method, while multivariate survival was analyzed with the Cox hazard model. FBXW7 suppression analysis was performed to examine proliferation potency and Myc expression in the FBXW7 siRNA groups. The relationship between FBXW7 expression and the copy number loss of FBXW7 was examined in clinical samples of ESCC. Finally, FBXW7 copy number loss was linked to prognosis in 42 ESCC patients. FBXW7 expression in cancer was lower compared to non-cancer tissues (P=0.003) and is an independent prognostic factor. The proliferation rates and Myc protein expression were significantly enhanced in FBXW7 siRNA cells compared to the controls. Cases with a loss of FBXW7 copy number had low FBXW7 expression and a poorer prognosis than cases with no...Continue Reading

Citations

Mar 25, 2015·Experimental and Molecular Pathology·Pingxiang WuLi Liang
Dec 23, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jianfei Qi, Ze'ev A Ronai
Aug 28, 2014·International Journal of Cancer. Journal International Du Cancer·Kojiro EtoHideo Baba
Apr 29, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·F YangJ Fu
Feb 23, 2019·Cancers·Bethsebie Lalduhsaki SailoAjaikumar Bahulayan Kunnumakkara
Sep 5, 2020·International Journal of Molecular Sciences·Gizem CelebiOzlem Kutlu
Jun 21, 2020·Cancers·Veronica GattiAngelo Peschiaroli

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