Copy number polymorphisms are not a common feature of innate immune genes.

Genomics
Rose M Linzmeier, T Ganz

Abstract

Extensive copy number polymorphism was recently reported for innate immunity-related alpha-defensin genes DEFA1 and DEFA3 and beta-defensin genes DEFB4, DEFB103, and DEFB104. To establish whether such polymorphisms are a common feature of innate immune genes we used quantitative real-time PCR to determine the copy numbers of seven genes whose products have important innate immune functions. The genes encoding lysozyme, lactoferrin, cathelicidin antimicrobial peptide (hCAP18/LL-37), cathepsin G, bactericidal/permeability-increasing protein, azurocidin (CAP37/heparin-binding protein), and neutrophil elastase were each found to be single copy per haploid genome. These findings, along with the recent observation that defensin genes DEFA4, DEFA5, DEFA6, and DEFB1 are single copy, suggest that copy number polymorphisms are not a common feature of the innate immune genome but are restricted to a small subset of innate immunity-related genes.

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Citations

Jan 31, 2007·British Journal of Sports Medicine·Alison V SeptemberMalcolm Collins
Sep 27, 2008·Genome Biology·Rachele CaglianiManuela Sironi
Jan 6, 2009·Ophthalmic Research·Alison M McDermott
Jan 27, 2010·BMC Evolutionary Biology·Paulina SchmittJulien de Lorgeril
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Dec 25, 2007·American Journal of Reproductive Immunology : AJRI·Alexander M Cole, Amy Liese Cole
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Jul 11, 2012·TheScientificWorldJournal·Chun-Tien ChangYun-Shien Lee
Apr 27, 2010·Innate Immunity·Tesfaldet TecleKevan L Hartshorn

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