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Copy number variation and evolution in humans and chimpanzees

Genome Research

Sep 9, 2008

George H PerryRichard Redon

Abstract

Copy number variants (CNVs) underlie many aspects of human phenotypic diversity and provide the raw material for gene duplication and gene family expansion. However, our understanding of their evolutionary significance remains limited. We performed comparative genomic hybridization on a...read more

Mentioned in this Paper

Fluorescent in Situ Hybridization
Gene Dosage
Systemic Inflammatory Response Syndrome
Genome
Segmental Duplications, Genomic
Array-Based Comparative Genomic Hybridization
Chromosomes, Human
Cell Proliferation
Cell Differentiation Process
Pan troglodytes
1
251
Paper Details
References
  • References64
  • Citations121
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  • References64
  • Citations121
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Hotspots for copy number variation in chimpanzees and humans

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Copy number variation and evolution in humans and chimpanzees

Genome Research

Sep 9, 2008

George H PerryRichard Redon

PMID: 18775914

DOI: 10.1101/gr.082016.108

Abstract

Copy number variants (CNVs) underlie many aspects of human phenotypic diversity and provide the raw material for gene duplication and gene family expansion. However, our understanding of their evolutionary significance remains limited. We performed comparative genomic hybridization on a...read more

Mentioned in this Paper

Fluorescent in Situ Hybridization
Gene Dosage
Systemic Inflammatory Response Syndrome
Genome
Segmental Duplications, Genomic
Array-Based Comparative Genomic Hybridization
Chromosomes, Human
Cell Proliferation
Cell Differentiation Process
Pan troglodytes
1
251

Similar Papers Found In These Feeds

Copy Number Variation

Copy number variation refers to alterations in the number of gene copies or DNA sequences. It can be a duplication, amplification, or a deletion event. Here is the latest research.

Whole Genome and Gene Duplications in Evolution

Gene and whole-genome duplications have occurred repeatedly and broadly throughout the evolutionary history of eukaryotes. Discover the latest research on Whole Genome and Gene Duplications in Evolution here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Hotspots for copy number variation in chimpanzees and humans

Proceedings of the National Academy of Sciences of the United States of AmericaMay 17, 2006
George H PerryCharles Lee
Paper Details
References
  • References64
  • Citations121
12345...
  • References64
  • Citations121
12345...
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