Copy number variation (CNV) and insecticide resistance in mosquitoes: evolving knowledge or an evolving problem?

Current Opinion in Insect Science
David WeetmanEric Lucas

Abstract

Copy number variation (CNV) in insect genomes is a rich source of potentially adaptive polymorphism which may help overcome the constraints of purifying selection on conserved genes and/or permit elevated transcription. Classic studies of amplified esterases and acetylcholinesterase duplication in Culex pipiens quantified evolutionary dynamics of CNV driven by insecticidal selection. A more complex and potentially medically impactful form of CNV is found in Anopheles gambiae, with both heterogeneous duplications and homogeneous amplifications strongly linked with insecticide resistance. Metabolic gene amplification, revealed by shotgun sequencing, appears common in Aedes aegypti, but poorly understood in other mosquito species. Many methodologies have been used to detect CNV in mosquitoes, but relatively few can detect both duplications and amplifications, and contrasting methods should be combined. Genome scans for CNV have been rare to date in mosquitoes, but offer immense potential to determine the overall role of CNV as a component of resistance mechanisms.

References

Oct 1, 1996·Biochemical Genetics·D BourguetM Arpagaus
Apr 5, 2002·Advances in Genetics·Sarah P Otto, Paul Yong
Sep 28, 2002·Science·I DenholmM S Williamson
Oct 5, 2002·Science·Hilary RansonRené Feyereisen
Nov 21, 2007·PLoS Genetics·Pierrick LabbéThomas Lenormand
May 6, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Haoués AloutMylène Weill
Apr 21, 2009·Malaria Journal·Luc DjogbénouMylène Weill
Oct 31, 2009·Insect Biochemistry and Molecular Biology·Haoués AloutMylène Weill
Jul 6, 2010·Insect Biochemistry and Molecular Biology·Kentaro ItokawaTakashi Tomita
Aug 17, 2010·Trends in Genetics : TIG·Wenfeng QianJianzhi Zhang
May 4, 2011·Pest Management Science·Chris Bass, Linda M Field
Nov 11, 2011·PLoS Genetics·Margarida Cardoso-MoreiraManyuan Long
Aug 31, 2012·Emerging Infectious Diseases·Constant V A EdiHilary Ranson
Aug 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Emily J RemnantPhilip Batterham
Feb 1, 2014·Evolution, Medicine, and Public Health·Ademir Jesus MartinsAlexandre Afranio Peixoto
Feb 6, 2014·Evolution; International Journal of Organic Evolution·Pierrick LabbéThomas Lenormand
Jun 6, 2015·Pesticide Biochemistry and Physiology·René FeyereisenThomas Van Leeuwen
Dec 1, 1998·Evolution; International Journal of Organic Evolution·Thomas LenormandMichel Raymond
Dec 1, 2017·Nature·UNKNOWN Anopheles gambiae 1000 Genomes ConsortiumUNKNOWN Project coordination

❮ Previous
Next ❯

Citations

Jul 28, 2019·Genome Research·Eric R LucasUNKNOWN Anopheles gambiae 1000 Genomes Consortium
May 20, 2020·G3 : Genes - Genomes - Genetics·Xuelian ChangGuiyun Yan
Aug 8, 2019·Scientific Reports·Walter Fabricio Silva MartinsMartin James Donnelly
Dec 1, 2020·BMC Biology·Yu-Hsuan ChengJun-Yi Leu
Feb 3, 2021·Wellcome Open Research·Jonathan ThorntonLisa Reimer
Nov 14, 2020·Communications Biology·Sylvie GimenezKiwoong Nam
Aug 28, 2021·BMC Developmental Biology·Antonio Celestino-MontesFidel de la Cruz Hernández-Hernández
Aug 25, 2021·Integrative and Comparative Biology·Erica CrespiJared V Goldstone
Dec 21, 2021·EMBO Molecular Medicine·Shunyi ZhuJan Tytgat

❮ Previous
Next ❯

Related Concepts