Coral: Clear and Customizable Visualization of Human Kinome Data

Cell Systems
Kathleen S MetzDouglas H Phanstiel

Abstract

Protein kinases represent one of the largest gene families in eukaryotes and play roles in a wide range of cell signaling processes and human diseases. Current tools for visualizing kinase data in the context of the human kinome superfamily are limited to encoding data through the addition of nodes to a low-resolution image of the kinome tree. We present Coral, a user-friendly interactive web application for visualizing both quantitative and qualitative data. Unlike previous tools, Coral can encode data in three features (node color, node size, and branch color), allows three modes of kinome visualization (the traditional kinome tree as well as radial and dynamic force networks), and generates high-resolution scalable vector graphics files suitable for publication without the need for refinement using graphics editing software. Due to its user-friendly, interactive, and highly customizable design, Coral is broadly applicable to high-throughput studies of the human kinome. The source code and web application are available at github.com/dphansti/CORAL and phanstiel-lab.med.unc.edu/Coral, respectively.

Citations

Jan 24, 2019·Science Signaling·Elise J NeedhamSean J Humphrey
Jan 7, 2020·Journal of Open Source Software·Amit MinDouglas H Phanstiel
Nov 26, 2020·Developmental Cell·Chongde WuYansheng Liu
Dec 22, 2020·British Journal of Pharmacology·Arnab DattaMark A Knepper
Jan 12, 2021·Journal for Immunotherapy of Cancer·Daan P HurkmansSjoerd H van der Burg
Mar 7, 2021·International Journal of Molecular Sciences·Manali TilakNina Jones
Mar 8, 2021·The Journal of Biological Chemistry·Marlene C GernerDavid M Baron
Mar 27, 2021·Scientific Reports·Ulrich BlacheJess G Snedeker
Apr 15, 2021·Science Signaling·Timothy R BaffiAlexandra C Newton
Jun 5, 2021·Journal of Medicinal Chemistry·Roberta TeschStefan Knapp
Jul 30, 2021·Clinical and Translational Medicine·Lazaro Hiram BetancourtGyörgy Marko-Varga
Aug 31, 2021·Clinical and Translational Medicine·Erika VelasquezGyörgy Marko-Varga
Sep 25, 2021·Nature Chemical Biology·Hannah C FeldmanDustin J Maly
Oct 30, 2021·Frontiers in Immunology·Erika VelásquezMelinda Rezeli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.