Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo.

The Journal of Infectious Diseases
Andrea SchieferKenneth Pfarr

Abstract

Doxycycline and rifampicin deplete essential Wolbachia from filarial nematodes that cause lymphatic filariasis or onchocerciasis, resulting in blocked worm development and death. However, doxycycline is contraindicated for children and pregnant/breastfeeding women, as is rifampicin in the latter group with the additional specter of possible resistance development in Mycobacterium spp. Novel antibiotics with a narrower spectrum would aid in eliminating filarial diseases. Corallococcus coralloides synthesizes corallopyronin A, a noncompetitive inhibitor of RNA polymerase ineffective against Mycobacterium spp. Corallopyronin A depleted Wolbachia from infected insect cells (1.89 Thus the antibiotic is effective against intracellular bacteria despite the many intervening surfaces (blood vessels, pleura, worm cuticle) and membranes (worm cell, vesicle, Wolbachia inner and outer membranes). Corallopyronin A is an antibiotic to develop further for filariasis elimination without concern for cross-resistance development in tuberculosis.

References

Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Feb 1, 1985·The Journal of Antibiotics·H IrschikH Reichenbach
Jan 28, 1999·Proceedings. Biological Sciences·C BandiM L Blaxter
Oct 19, 2000·Antimicrobial Agents and Chemotherapy·A O'NeillI Chopra
Apr 12, 2001·Tropical Medicine & International Health : TM & IH·P EsterreN L Nguyen
Feb 24, 2006·Antimicrobial Agents and Chemotherapy·Benjamin L MakepeaceAlexander J Trees
Apr 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph D TurnerAchim Hoerauf
Oct 19, 2006·PLoS Pathogens·Alexander Yaw DebrahAchim Hoerauf
Dec 13, 2006·Nature Biotechnology·Jon ClardyChristopher T Walsh
Sep 12, 2007·Bioinformatics·M A LarkinD G Higgins
Dec 14, 2007·Tropical Medicine & International Health : TM & IH·Alexander Yaw DebrahAchim Hoerauf
Apr 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Taniawati SupaliErliyani Sartono
Aug 6, 2008·Parasitology Research·Sabine SpechtAchim Hoerauf
Oct 24, 2008·Nature·Georgiy A BelogurovDmitry G Vassylyev
Oct 30, 2008·Cell·Jayanta MukhopadhyayRichard H Ebright
Nov 4, 2008·Current Opinion in Infectious Diseases·Achim Hoerauf
Jun 3, 2009·Expert Review of Anti-infective Therapy·Moses J BockarieJohn O Gyapong
Aug 22, 2009·Current Opinion in Microbiology·Michael A Fischbach
Oct 15, 2009·Parasite Immunology·K M PfarrA Hoerauf
Nov 21, 2009·Current Opinion in Structural Biology·Mary X HoRichard H Ebright
May 27, 2010·Chembiochem : a European Journal of Chemical Biology·Ozlem ErolGabriele M König
Aug 27, 2010·Lancet·Mark J TaylorMoses Bockarie
Apr 7, 2011·PLoS Neglected Tropical Diseases·Mike Y Osei-AtweneboanaRoger K Prichard
Jul 5, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A HoeraufS Specht

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Citations

Oct 2, 2013·International Journal of Medical Microbiology : IJMM·Till F SchäberleKenneth Pfarr
Dec 18, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Kelly L JohnstonMark J Taylor
Oct 3, 2015·Journal of Natural Products·Till F SchäberleGabriele M König
Feb 13, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T BoucheryC Martin
Dec 3, 2016·Natural Product Reports·J HerrmannR Müller
Dec 23, 2015·Natural Product Reports·Eric J N Helfrich, Jörn Piel
Nov 1, 2018·Applied Microbiology and Biotechnology·Dieter Jendrossek, Jakob Birke
Aug 6, 2019·PLoS Neglected Tropical Diseases·Marc P HübnerAchim Hoerauf
May 21, 2014·Natural Product Reports·Till F SchäberleGabriele M König
Jun 25, 2016·Beilstein Journal of Organic Chemistry·Till F Schäberle
Sep 24, 2019·Natural Product Reports·Raúl G Saraiva, George Dimopoulos
Jun 25, 2013·Chembiochem : a European Journal of Chemical Biology·Stephan FelderGabriele M König
Jul 22, 2019·Tropical Medicine and Infectious Disease·Malina A Bakowski, Case W McNamara
Jun 18, 2016·Archiv der Pharmazie·Katja M Fisch, Till F Schäberle
Jan 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·W David HongPaul M O'Neill
May 10, 2019·Science Translational Medicine·Malina A BakowskiCase W McNamara
Apr 27, 2019·Microbiology Resource Announcements·Sarah BouhiredGabriele König
Sep 10, 2019·The Indian Journal of Medical Research·Wan Aliaa Wan SulaimanHamidon Basri
Nov 13, 2015·Chemical Science·Georg ZocherThilo Stehle
Dec 8, 2020·PLoS Neglected Tropical Diseases·Andrea SchieferAchim Hoerauf
Jul 18, 2021·International Journal for Parasitology·Mamta GangwarMrigank Srivastava
Feb 25, 2020·ACS Infectious Diseases·Natalie A Hawryluk
Jan 16, 2014·Journal of Natural Products·Alexander SchmitzGabriele M König
Aug 25, 2021·Nature Reviews. Chemistry·Marcus MiethkeRolf Müller
Aug 29, 2021·Pharmaceutics·Mudasir Ahmad BhatArif Tasleem Jan
Oct 14, 2021·Parasitology Research·Adela NgwewondoSabine Specht

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