Corannulene-Incorporated AIE Nanodots with Highly Suppressed Nonradiative Decay for Boosted Cancer Phototheranostics In Vivo

Advanced Materials
Xinggui GuBen Zhong Tang

Abstract

Fluorescent nanoparticles (NPs) based on luminogens with aggregation-induced emission characteristic (AIEgens), namely AIE dots, have received wide attention because of their antiquenching attitude in emission and reactive oxygen species (ROS) generation when aggregated. However, few reports are available on how to control and optimize their fluorescence and ROS generation ability. Herein, it is reported that enhancing the intraparticle confined microenvironment is an effective approach to advanced AIE dots, permitting boosted cancer phototheranostics in vivo. Formulation of a "rotor-rich" and inherently charged near-infrared (NIR) AIEgen with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] and corannulene-decorated PEG affords DSPE-AIE dots and Cor-AIE dots, respectively. Compared to DSPE-AIE dots, Cor-AIE dots show 4.0-fold amplified fluorescence quantum yield and 5.4-fold enhanced ROS production, because corannulene provides intraparticle rigidity and strong interactions with the AIEgen to restrict the intramolecular rotation of AIEgen to strongly suppress the nonradiative decay and significantly facilitate the fluorescence pathway and intersystem crossing. Thus, it tremendously promotes...Continue Reading

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Citations

Feb 13, 2020·Angewandte Chemie·Zheng ZhaoBen Zhong Tang
Sep 24, 2019·Nanoscale·Ruoyu ZhangBin Liu
Jul 10, 2019·Frontiers in Chemistry·Meng LiHuining Xiao
Jul 1, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Artur KasprzakHidehiro Sakurai
Mar 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Nicholas E Wojtynek, Aaron M Mohs
Nov 17, 2020·Chemical Society Reviews·Guangxue FengDan Ding
Dec 22, 2020·Advanced Science·Sandhya ClementEwa M Goldys
Feb 11, 2020·Journal of Medicinal Chemistry·Jun DaiYuning Hong
May 19, 2021·Chemical Communications : Chem Comm·Yali WangNathaniel S Finney
Aug 21, 2021·Advanced Healthcare Materials·Jun DaiShixuan Wang
Aug 22, 2021·Advanced Healthcare Materials·Yuqing WangXing-Jie Liang
Dec 22, 2020·Journal of the American Chemical Society·Hogeun ChangTaeghwan Hyeon
Mar 11, 2020·The Journal of Organic Chemistry·Sergio FerreroCeledonio M Álvarez
Sep 15, 2021·Advanced Healthcare Materials·Menglei ZhaKai Li
Sep 16, 2021·Chemical Communications : Chem Comm·Gabrielle A Leith, Natalia B Shustova

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