Cord Blood as a Source of Natural Killer Cells

Frontiers in Medicine
Rohtesh S MehtaKatayoun Rezvani

Abstract

Cord blood (CB) offers several unique advantages as a graft source for hematopoietic stem cell transplantation (HSCT). The risk of relapse and graft vs. host disease after cord blood transplantation (CBT) is lower than what is typically observed after other graft sources with a similar degree of human leukocyte antigen mismatch. Natural killer (NK) cells have a well-defined role in both innate and adaptive immunity and as the first lymphocytes to reconstitute after HSCT and CBT, and they play a significant role in protection against early relapse. In this article, we highlight the uses of CB NK cells in transplantation and adoptive immunotherapy. First, we will describe differences in the phenotype and functional characteristics of NK cells in CB as compared with peripheral blood. Then, we will review some of the obstacles we face in using resting CB NK cells for adoptive immunotherapy, and discuss methods to overcome them. We will review the current literature on killer-cell immunoglobulin-like receptors ligand mismatch and outcomes after CBT. Finally, we will touch on current strategies for the use of CB NK cells in cellular immunotherapy.

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Citations

Aug 11, 2017·Journal of Virology·Silke PaustR Keith Reeves
Apr 18, 2019·Journal of Cellular Physiology·Behnaz ValipourHojjatollah Nozad Charoudeh
Nov 20, 2019·Journal of Clinical Medicine·Hyun Don YunClaudio Brunstein
Jun 18, 2020·Stem Cell Research & Therapy·Keerthana ShankarKrishanu Saha
Aug 6, 2020·Cancers·S Elizabeth FranksJames W Hodge
Nov 21, 2020·British Journal of Haematology·Hind RafeiKatayoun Rezvani
Jan 22, 2021·Stem Cells Translational Medicine·Sabrina Bianca BennsteinMarkus Uhrberg
Nov 17, 2020·Frontiers in Immunology·Xiaoyan ZhaoHuafang Wang

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Methods Mentioned

BETA
PCR
flow cytometry

Clinical Trials Mentioned

NCT01619761
NCT01729091
NCT02280525
NCT01823198

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