PMID: 16509522Mar 3, 2006Paper

Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins

Journal of Pediatric Endocrinology & Metabolism : JPEM
Bettina C GohlkeChristian L Roth

Abstract

To investigate a potential role of leptin and insulin-like growth factor (IGF)-I on fetal growth and metabolic function we determined plasma leptin and IGF-I concentrations in twins in relation to discordant fetal growth. In studying monochorionic twins with inter-twin birth weight difference, we investigated the relative contribution of genetic (fetus) versus environmental (maternal/placental) factors on growth. Thirty-six sets of twins (14 with discordant growth, birth weight difference >15%) who had been treated for severe twin-to-twin transfusion syndrome (TTTS) by laser coagulation were studied. Cord blood samples were collected at birth and analyzed for IGF-I and leptin. Inter-twin differences (delta) of birth weight and head circumference were correlated to delta hormone levels. An inter-twin correlation for leptin (r = 0.69; p <0.0001) and delta IGF-I (r = 0.49; p <0.0001) was found. delta birth weight correlated significantly with delta IGF-I (r = 0.67; p <0.0001) but not with delta leptin (r = 0.23; p = 0.19). delta IGF-I concentrations did not correlate with delta leptin (r = 0.18). delta head circumference correlated significantly with delta leptin (r = 0.47; p <0.01) and with delta IGF-I (r = 0.46; p <0.01). Using ...Continue Reading

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Citations

Jan 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·R Alan HarrisKjersti M Aagaard
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Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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