Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic "T(H)2-type" immunity associated with development of food allergy

Science Translational Medicine
Yuxia ZhangBIS Investigator Group

Abstract

Food allergy is a major health burden in early childhood. Infants who develop food allergy display a proinflammatory immune profile in cord blood, but how this is related to interleukin-4 (IL-4)/T helper 2 (T(H)2)-type immunity characteristic of allergy is unknown. In a general population-derived birth cohort, we found that in infants who developed food allergy, cord blood displayed a higher monocyte to CD4(+) T cell ratio and a lower proportion of natural regulatory T cell (nT(reg)) in relation to duration of labor. CD14(+) monocytes of food-allergic infants secreted higher amounts of inflammatory cytokines (IL-1β, IL-6, and tumor necrosis factor-α) in response to lipopolysaccharide. In the presence of the mucosal cytokine transforming growth factor-β, these inflammatory cytokines suppressed IL-2 expression by CD4(+) T cells. In the absence of IL-2, inflammatory cytokines decreased the number of activated nT(reg) and diverted the differentiation of both nT(reg) and naïve CD4(+) T cells toward an IL-4-expressing nonclassical TH2 phenotype. These findings provide a mechanistic explanation for susceptibility to food allergy in infants and suggest anti-inflammatory approaches to its prevention.

References

Sep 20, 2002·The New England Journal of Medicine·Charlotte Braun-FahrländerUNKNOWN Allergy and Endotoxin Study Team
Sep 21, 2002·Lancet·Roger P LauenerUNKNOWN ALEX study group
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stuart G TangyePhilip D Hodgkin
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susan C McKarnsNorbert E Kaminski
Aug 13, 2004·European Journal of Immunology·Maurus de la RosaAlexander Scheffold
Apr 25, 2006·The Journal of Allergy and Clinical Immunology·Markus Johannes EgeUNKNOWN Parsifal Study team
Apr 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M WaserUNKNOWN PARSIFAL Study team
May 6, 2008·The Journal of Allergy and Clinical Immunology·Miranda SmithSusan L Prescott
Jun 24, 2008·The Journal of Allergy and Clinical Immunology·Susan L PrescottMeri K Tulic
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Masaki KashiwadaPaul B Rothman
Mar 3, 2010·Annual Review of Immunology·Jinfang ZhuWilliam E Paul
Mar 26, 2010·Nature Reviews. Immunology·William E Paul, Jinfang Zhu
May 14, 2010·The Journal of Allergy and Clinical Immunology·Scott H SichererHugh A Sampson
Jun 19, 2010·Nature Reviews. Immunology·Shimon SakaguchiDavid A Hafler
Jul 9, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N J OsborneUNKNOWN HealthNuts Study Investigators
Nov 26, 2010·The Journal of Allergy and Clinical Immunology·Meri K TulicSusan L Prescott
Feb 25, 2011·The New England Journal of Medicine·Markus J EgeUNKNOWN GABRIELA Transregio 22 Study Group
Mar 8, 2011·The Journal of Allergy and Clinical Immunology·Nicholas J OsborneUNKNOWN HealthNuts Investigators
Aug 31, 2011·The Journal of Allergy and Clinical Immunology·Georg LossUNKNOWN GABRIELA study group
Nov 15, 2011·The Journal of Allergy and Clinical Immunology·Jennifer J KoplinUNKNOWN HealthNuts investigators
Dec 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alicia BensonFelix Yarovinsky
Feb 3, 2012·Cold Spring Harbor Perspectives in Biology·Kim Newton, Vishva M Dixit
Nov 12, 2013·Allergy·B I NwaruUNKNOWN EAACI Food Allergy and Anaphylaxis Guidelines Group
Dec 7, 2013·The World Allergy Organization Journal·Susan L PrescottBee-Wah Lee
Aug 26, 2014·Immunity·Irma TindemansRudi W Hendriks
Sep 10, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Claudia L GrayGeorge du Toit
Nov 5, 2014·Nature·Kyle Kai-How FarhBradley E Bernstein
Nov 8, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Intan H IsmailMimi L K Tang
Mar 20, 2015·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov
Apr 2, 2015·International Journal of Epidemiology·Peter VuillerminAnne-Louise Ponsonby
Apr 11, 2015·Clinical & Translational Immunology·Fiona M CollierAnne-Louise Ponsonby

❮ Previous
Next ❯

Citations

Feb 24, 2016·Nature Reviews. Immunology·Lucy Bird
May 9, 2016·The Journal of Allergy and Clinical Immunology·Stephen Joseph Galli
Sep 8, 2016·Trends in Immunology·Paul J Bryce
Jan 15, 2017·The Journal of Allergy and Clinical Immunology·Regina K RoweMichelle A Gill
Jun 20, 2017·Nature Reviews. Immunology·Xiaoming ZhangRichard Lo-Man
Nov 25, 2017·Seminars in Immunopathology·Mikael KnipTaina Härkönen
Sep 14, 2017·Seminars in Immunopathology·Dania Zhivaki, Richard Lo-Man
Oct 19, 2017·Seminars in Immunopathology·Peter J VuillerminSusanne Brix
May 4, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter S HsuRalph Nanan
Aug 17, 2016·Pediatric Diabetes·Jessica E PhillipsUNKNOWN ENDIA Study Group
Jun 22, 2017·Current Allergy and Asthma Reports·Rachel L PetersKatrina J Allen
May 8, 2020·Immunology and Cell Biology·Dian YuPing-Chang Yang
Nov 1, 2016·Nature Reviews. Immunology·Wong YuKari C Nadeau
Oct 20, 2017·American Journal of Respiratory and Critical Care Medicine·Fernando D Martinez, Stefano Guerra
May 15, 2018·International Journal of Molecular Sciences·Yosef EllenbogenManel Jordana
Aug 19, 2018·Nature Communications·David MartinoRichard Saffery
Mar 27, 2020·Nature Communications·Peter J VuillerminUNKNOWN BIS Investigator Group
Mar 5, 2019·The Journal of Clinical Investigation·Andrea M Kemter, Cathryn R Nagler
Oct 20, 2020·Frontiers in Immunology·Melanie R NeelandRichard Saffery
Jan 13, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steffen U ThorsenUNKNOWN Barwon Infant Study Investigator Group
Dec 19, 2020·The Journal of Allergy and Clinical Immunology·Jenni LehtimäkiJakob Stokholm
Jan 26, 2021·Frontiers in Immunology·Elise G LiuStephanie C Eisenbarth
Dec 18, 2020·Frontiers in Immunology·Lijun YangQing Ge
Sep 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Faisal ShahJinchuang Zhang
Feb 25, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Melanie R NeelandRichard Saffery
Feb 18, 2018·The Journal of Allergy and Clinical Immunology·Katherine A WeisslerPamela A Frischmeyer-Guerrerio
Feb 28, 2021·Annual Review of Immunology·Siroon BekkeringMihai G Netea
May 5, 2021·The Journal of Experimental Medicine·Xiaoying ZhouKari C Nadeau
Feb 10, 2019·The Journal of Allergy and Clinical Immunology·M Cecilia Berin
Jun 24, 2021·Annals of the New York Academy of Sciences·Justine C Noel, M Cecilia Berin
Jun 26, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Sean R HolmCatherine A Thornton
Jul 27, 2021·The Journal of Allergy and Clinical Immunology·Yuan GaoPeter Vuillermin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.