PMID: 8597353Dec 29, 1995Paper

Cord blood transplantation and the potential for gene therapy. Gene transduction using a recombinant adeno-associated viral vector

Annals of the New York Academy of Sciences
Hal E BroxmeyerA Srivastava

Abstract

Cord blood, which contains a high frequency of immature stem/progenitor cells with extensive proliferative and replating capacity in vitro was used as a clinical source of transplantable stem and progenitor cells. These cells can be efficiently transduced with new genetic material by using AAV or retroviral vectors. Using a recombinant AAV vector, high level expression of the lacZ gene under a CMV promoter was demonstrated in immature subsets of cord blood progenitor cells.

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H E BroxmeyerP Rubinstein
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H E BroxmeyerE A Boyse
Jun 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J GaddyH E Broxmeyer
Sep 1, 1993·The Journal of Experimental Medicine·P M LansdorpH Mayani
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A A CardosoS C Clark
Feb 1, 1995·Current Opinion in Pediatrics·H E Broxmeyer
Feb 9, 1995·The New England Journal of Medicine·S IssaragrisilA Piankijagum
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·G RisdonH E Broxmeyer
Mar 1, 1994·The Journal of Clinical Investigation·H E Broxmeyer
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·R N PahwaR A Good

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Citations

May 16, 1998·Plastic and Reconstructive Surgery·M H HedrickM R Harrison
Sep 22, 1999·Gene Therapy·L DingN Munshi
May 12, 2017·Human Gene Therapy·Nolan BrownMatthew L Hirsch
Aug 11, 1997·Advanced Drug Delivery Reviews·M J During

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