Cord blood transplantation for acute leukemia.

Expert Opinion on Biological Therapy
Mattia AlgeriFranco Locatelli

Abstract

Umbilical cord blood transplantation (UCBT) is a suitable alternative for patients with acute leukemia (AL) in need of an allograft and who lack an HLA-matched donor. Single-institution and registry studies have shown that, in both children and adults with AL, the outcome of UCBT is comparable to that of matched unrelated donor. At the same time, these studies have highlighted some limitations of UCBT, such as increased early mortality and delayed recovery of both hematopoietic and immune compartment, which hamper a more widespread adoption of this approach. In this review, we will analyze the current results of UCBT in children and adults with AL, including comparisons with other hematopoietic stem cell sources and transplant strategies. We will also discuss important factors to be considered when selecting UCB units, as well as future strategies to further improve the outcome of UCBT recipients. The utilization of UCBT for the treatment of AL patients has decreased in recent years. However, recent clinical data suggesting that UCBT might offer better results in patients with minimal residual disease, as well as innovative strategies to facilitate engraftment, reduce transplant-related mortality, and optimize anti-leukemic act...Continue Reading

References

Jul 18, 1996·The New England Journal of Medicine·J KurtzbergP Rubinstein
Nov 26, 1998·The New England Journal of Medicine·P RubinsteinC E Stevens
Jun 16, 2001·The New England Journal of Medicine·M J LaughlinJ Kurtzberg
Aug 13, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Elizabeth J ShpallIan K McNiece
Mar 31, 2004·Experimental Hematology·Eliane GluckmanUNKNOWN Eurocord Group
Nov 27, 2004·The New England Journal of Medicine·Mary J LaughlinMary M Horowitz
Nov 27, 2004·The New England Journal of Medicine·Vanderson RochaUNKNOWN Eurocord-Netcord Registry
Apr 28, 2006·The New England Journal of Medicine·Edward A Copelan
Apr 25, 2007·Cytotherapy·P Szabolcs, D Niedzwiecki
Dec 18, 2007·Bone Marrow Transplantation·V Rocha, F Locatelli
Dec 2, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jun OoiShigetaka Asano
Apr 2, 2009·Haematologica·Eliane Gluckman, Vanderson Rocha
Oct 3, 2009·British Journal of Haematology·Franco Locatelli
Oct 3, 2009·British Journal of Haematology·Vanderson RochaUNKNOWN Eurocord-Netcord registry and European Blood and Marrow Transplant group
Jun 19, 2010·The Lancet Oncology·Mary EapenUNKNOWN National Cord Blood Program of the New York Blood Center
Aug 31, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Juliet N BarkerMarcel R M van den Brink
Aug 31, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Caron A JacobsonJerome Ritz
Sep 29, 2011·Bone Marrow Transplantation·P RamirezC G Brunstein

❮ Previous
Next ❯

Citations

Apr 20, 2021·Frontiers in Cell and Developmental Biology·Muneerah A H HuwaikemPeter N Pushparaj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.