Cordance derived from REM sleep EEG as a biomarker for treatment response in depression--a naturalistic study after antidepressant medication

Journal of Psychiatric Research
Marek AdamczykMarcel Pawlowski

Abstract

To evaluate whether prefrontal cordance in theta frequency band derived from REM sleep EEG after the first week of antidepressant medication could characterize the treatment response after 4 weeks of therapy in depressed patients. 20 in-patients (15 females, 5 males) with a depressive episode and 20 healthy matched controls were recruited into 4-week, open label, case-control study. Patients were treated with various antidepressants. No significant differences in age (responders (mean ± SD): 45 ± 22) years; non-responders: 49 ± 12 years), medication or Hamilton Depression Rating Scale (HAM-D) score (responders: 23.8 ± 4.5; non-responders 24.5 ± 7.6) at inclusion into the study were found between responders and non-responders. Response to treatment was defined as a ≥50% reduction of HAM-D score at the end of four weeks of active medication. Sleep EEG of patients was recorded after the first and the fourth week of medication. Cordance was computed for prefrontal EEG channels in theta frequency band during tonic REM sleep. The group of 8 responders had significantly higher prefrontal theta cordance in relation to the group of 12 non-responders after the first week of antidepressant medication. This finding was significant also whe...Continue Reading

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Citations

Jul 8, 2015·Translational Psychiatry·M AdamczykE Friess
Sep 26, 2019·Psychiatry Investigation·Chien-Han Lai
Feb 3, 2019·International Journal of Molecular Sciences·Axel Steiger, Marcel Pawlowski
Dec 29, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chien-Han Lai

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