Corded and hyalinized mesonephric-like adenocarcinoma of the uterine corpus: report of a case mimicking endometrioid carcinoma

Human Pathology
Vatsal PatelJ Kenneth Schoolmeester

Abstract

Mesonephric-like adenocarcinoma is a recently described adenocarcinoma of the uterine body and ovary with overlapping features of mesonephric adenocarcinoma and endometrioid carcinoma. It is thought to be a mullerian adenocarcinoma that has differentiated along mesonephric lines. A 71-year-old woman had a 3-cm endometrial mass that invaded the myometrium without gross or microscopic evidence of cervical involvement. The tumor had a variety of architectural patterns and produced prominent stromal hyalinization containing embedded cords and trabeculae of tumor cells. No squamous or mucinous differentiation or associated mesonephric remnants or hyperplasia was identified. The tumor was positive for TTF1 and GATA3, very focally and weakly positive for estrogen receptor and negative for progesterone receptor and nuclear expression of β-catenin. An unusual inverse pattern of TTF1 and GATA3 immunoreactivity was observed. DNA analysis by digital droplet polymerase chain reaction and quantitative polymerase chain reaction identified an activating KRAS (G12A) mutation. The tumor was interpreted as corded and hyalinized mesonephric-like adenocarcinoma that mimicked corded and hyalinized endometrioid carcinoma.

Citations

Nov 15, 2019·The American Journal of Surgical Pathology·Elizabeth D EuscherAnais Malpica
Nov 13, 2019·The American Journal of Surgical Pathology·Jennifer PorsLynn N Hoang
Nov 20, 2019·Diagnostic Pathology·Meng JiaHongwen Gao
Jun 30, 2021·The American Journal of Surgical Pathology·Ellen DeoletW Glenn McCluggage

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.