PMID: 4118874Dec 1, 1972

Cordycepin inhibits induction of murine leukovirus production by 5-iodo-2'-deoxyuridine

Proceedings of the National Academy of Sciences of the United States of America
A M WuR C Gallo

Abstract

Cordycepin (3'-deoxyadenosine), an inhibitor of poly(A) synthesis during the processing of nuclear heterogenous RNA, blocks the production of RNA viruses induced by 5-iodo-2'-deoxyuridine in BALB/3T3 and BALB/K-3T3 cells. This inhibitory activity is not a result of either nonspecific cell killing or general cytotoxicity by cordycepin; rather, it appears to be specific, because cordycepin acts only at a critical time to inhibit virus production. These findings, together with the finding of poly(A) sequences in viral RNAs, suggest that RNA tumor viruses replicate via a transcription of proviral DNA.

References

Jun 27, 1970·Nature·H M Temin, S Mizutani
Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D Baltimore, D Smoler
Nov 1, 1971·The Journal of General Virology·S A Aaronson, C A Weaver
Apr 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·M Green, M Cartas
Apr 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·W SiegertP H Hofschneider
Jan 1, 1971·Annual Review of Microbiology·H M Temin
Nov 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·R J Huebner, G J Todaro
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·L PhilipsonJ E Darnell

Citations

Jan 1, 1992·Cancer Chemotherapy and Pharmacology·K R SvendsenL L Vindeløv
Nov 1, 1974·In Vitro·D R LowyS K Chattopadhyay
Dec 11, 1978·Biochimica Et Biophysica Acta·M G SarngadharanR C Gallo
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M ParanA M Wu
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A M WuR C Gallo
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P LonaiH S Kaplan
Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C MoroniD Martin
Mar 4, 1977·Annals of the New York Academy of Sciences·P ChandraA Götz
Mar 4, 1977·Annals of the New York Academy of Sciences·D Gillespie, R C Gallo
Jul 26, 1979·Biochimica Et Biophysica Acta·C Sander, L A Hadwiger
Jan 1, 1980·Pharmacology & Therapeutics·Y Becker
Jan 1, 1979·Experimental Cell Research·A D Deitch, S G Sawicki
Mar 1, 1976·Biochemical Pharmacology·R G Smith, R C Gallo
Jun 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peng QinDengXue Lu
Mar 15, 1975·International Journal of Cancer. Journal International Du Cancer·L S RichardsonA M Wu
Jul 15, 1977·International Journal of Cancer. Journal International Du Cancer·M S ReitzR C Gallo
Oct 15, 1974·International Journal of Cancer. Journal International Du Cancer·R W TennantL McGrath
Nov 1, 1978·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J B RobertsonJ B Little

Related Concepts

Adenocard
Cyclic AMP, (R)-Isomer
Ceftina
Ac-De
Deoxyadenosines
Deoxyuridine
RNA-Directed DNA Polymerase
Viper retrovirus

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