Core 2 β-1, 6-N-acetylglucosaminyltransferase-1 expression in prostate biopsy specimen is an indicator of prostate cancer aggressiveness

Biochemical and Biophysical Research Communications
Tendo SatoChikara Ohyama

Abstract

To avoid over-treatment of early stage prostate cancer (PCa), predictive biomarkers for PCa aggressiveness which can be obtained during pre-treatment evaluation are essential. Core 2 β-1, 6-N-acetylglucosaminyl-transferase-1 (GCNT1) is a key enzyme that forms core 2 branched O-glycans, the expression of which is associated with aggressive potential of prostate cancer. We examined whether GCNT1 expression in prostate biopsy specimen can predict cancer recurrence after radical prostatectomy for the patients with with PCa. We then investigated molecular background for aggressive malignant potential mediated by GCNT1 expression. Paraffin-embedded PCa biopsy specimens were immunohisto-chemically tested for GCNT1 expression using an anti-GCNT1 monoclonal antibody. We also examined the role of GCNT1 in PCa progression using cell lines which express high or low levels of GCNT1. GCNT1 expression correlated with D' Amico's recurrence risk classification. The GCNT1-positive rate in organ confined PCa was significantly lower than that in PCa with extra-prostatic extension. GCNT1-negative tumors were associated with significantly better prostate-specific antigen (PSA)-free survival compared with GCNT1-positive tumors. Multivariate analysis ...Continue Reading

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Citations

Feb 6, 2017·Endocrine-related Cancer·Jennifer Munkley
Nov 20, 2018·Expert Review of Proteomics·Jan TkacPeter Kasak
Mar 22, 2019·International Journal of Molecular Sciences·Emma Scott, Jennifer Munkley
Mar 13, 2019·Metabolites·Nuria Gómez-CebriánLeonor Puchades-Carrasco
Oct 13, 2016·International Journal of Clinical Oncology·Shingo HatakeyamaChikara Ohyama
Jun 26, 2020·Glycoconjugate Journal·Ruifeng BaiYin Gao
Oct 18, 2020·Journal of Personalized Medicine·Yugang WenXiao-Feng Sun
Nov 1, 2020·Molecular & Cellular Proteomics : MCP·Rebeca KawaharaGiuseppe Palmisano
Aug 8, 2021·Cancers·Anna KałużaMirosława Ferens-Sieczkowska

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