Apr 16, 2020

Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells

BioRxiv : the Preprint Server for Biology
L. AugustoWilliam J Sullivan

Abstract

Toxoplasma gondii is an intracellular parasite that reconfigures its host cell to promote pathogenesis. One consequence of Toxoplasma parasitism is increased migratory activity of host cells, which facilitates dissemination. Here we show that Toxoplasma triggers the unfolded protein response (UPR) in host cells through calcium release from the endoplasmic reticulum (ER). We further found that host IRE1, an ER stress sensor protein activated during Toxoplasmainfection, also plays a noncanonical role in actin remodeling by binding filamin A in infected cells. By inducing cytoskeletal remodeling via IRE1 oligomerization in host cells, Toxoplasma enhances host cell migration in vitro and dissemination of the parasite to host organs in vivo. Our study identifies novel mechanisms used by Toxoplasma to induce dissemination of infected cells, providing new insights into strategies for treatment of toxoplasmosis.

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Mentioned in this Paper

Size
Genes
Definition
Salmonella enterica
Environment
Laboratory
Escherichia coli
Central Cores
Positive Selection
Entamoeba coli

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