Core imprint cytology of screen-detected breast lesions is predictive of the histologic results

Cancer
Gelareh Farshid, Steve Pieterse

Abstract

In multidisciplinary assessment clinics for screen-detected breast lesions, onsite cytopathologists provide immediate results of fine-needle aspiration biopsies (FNABs) and this information is used for patient counseling and treatment planning. Such consultation is not possible for the increasing proportion of lesions that are being assessed by core biopsy. If core imprint cytology (CIC) of breast cores can be shown to be reliable in a significant proportion of screen-detected lesions, this technique may be of clinical value in such clinics. In the setting of a large, accredited, population-based breast cancer screening program, prospective results of CIC were gathered on 567 lesions and correlated with the results of core biopsy to determine the performance indicators for CIC. The positive predictive value of a diagnosis of malignancy on CIC was 98.2% and the negative predictive value was 77.8%. The absolute sensitivity was 42.2%, complete sensitivity (inclusive of suspicious and atypical results) was 86.4%, absolute specificity was 56.3%, and total specificity (inclusive of acellular imprints) was 83.7%. The 2 false-positive imprints had atypical ductal hyperplasia on core histology but were found to be ductal carcinoma in si...Continue Reading

References

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Jun 5, 2004·The Breast : Official Journal of the European Society of Mastology·A R CarmichaelR Boparai

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Citations

Feb 24, 2007·Breast Cancer Research and Treatment·Elisabeth Mueller-HolznerChristian Marth
Jul 10, 2007·Breast Cancer Research and Treatment·Takayoshi Uematsu, Masako Kasami
Jan 16, 2007·Current Opinion in Obstetrics & Gynecology·Benjaporn Chaiwun, Paul Thorner
Dec 15, 2012·Breast Cancer Research and Treatment·Joris P BulteJohannes H W De Wilt
Aug 17, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C A P WautersL J A Strobbe
Aug 17, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B KooistraT Wobbes
Jun 12, 2010·Cancer Epidemiology·Vimal RajM Al-Attar
Sep 12, 2009·Cytopathology : Official Journal of the British Society for Clinical Cytology·C Engohan-AlogheJ-C Noël

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Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

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