Core myopathies and risk of malignant hyperthermia

Anesthesia and Analgesia
Werner KlinglerPhilip Hopkins


In this article, we analyze myopathies with cores, for which an association to malignant hyperthermia (MH) has been suggested. We discuss the clinical features, the underlying genetic defects, subsequent effects on cellular calcium metabolism, and in vitro muscle responses to MH triggers. We describe in detail central core disease, multiminicore disease, and nemaline rod myopathy. We categorize the diseases according to the affected proteins and discuss the risk for MH, which is high or theoretically possible when the calcium-conducting proteins are affected.


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Related Concepts

Anesthesia Procedures
Malignant Hyperpyrexia due to Anesthesia
Nemaline Myopathy, Late Onset
Soleus Muscle Structure
Benefit-Risk Assessment
Ryanodine Receptor 3
Genetic Predisposition to Disease
Central Core Myopathy (Disorder)

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