Core outcomes in gestational diabetes for treatment trials: The Gestational Metabolic Group treatment set.

Obesity Science & Practice
Mohammed BashirSuhail A R Doi

Abstract

With the rising number of outcomes being reported following gestational diabetes (GDM), the outcomes in existing studies vary widely making it challenging to compare and contrast the effectiveness of different interventions for GDM. The purpose of this study was to develop a core outcome and measurement set (COS) for GDM treatment trials. A Delphi study with structured consultation with stakeholders and discussion within a specialist Gestational Metabolic Group (GEM) were combined with a comprehensive systematic search across different databases (PubMed, Cochrane Library, and Embase). Several Delphi rounds over 2 years were conducted culminating in this report. The process resulted in a targeted set of outcomes constituting a "GEM treatment set" aligned with expert opinion. The final COS also included a measurement set for the 11 important clinical outcomes from three major domains: maternal metabolic, fetal, and pregnancy related. Based on the results of this study, it is recommended that future clinical trials on GDM report outcomes uniformly keeping to the recommended COS outcomes.

References

Apr 12, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·T FarrellT Cundy
Mar 19, 2004·British Journal of Community Nursing·Jane AllenMargaret Jones
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Dec 23, 2009·Obstetrics and Gynecology·Lisa E MooreLuis B Curet
Jan 16, 2010·Health Affairs·Timothy M DallJeanene Fogli
Feb 17, 2010·BMJ : British Medical Journal·Jamie J KirkhamPaula R Williamson
Feb 24, 2010·Obstetrics and Gynecology·Monique M HeddersonAssiamira Ferrara
Dec 15, 2010·International Journal of Women's Health·Catherine Kim
Apr 17, 2012·Journal of Perinatal Medicine·Jean Carl SilvaAnna Maria Bertini
Feb 20, 2013·Journal of Clinical Epidemiology·Siw WaffenschmidtThomas Kaiser
Mar 26, 2013·American Journal of Obstetrics and Gynecology·Cristiane Pavão SpaulonciRossana Pulcineli Vieira Francisco
Dec 5, 2013·Diabetes Research and Clinical Practice·L GuariguataN H Cho
Dec 11, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A A MamunS A R Doi
Jul 16, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C SongX Yang
Sep 3, 2017·Drugs·Geetha Mukerji, Denice S Feig
Nov 18, 2017·PLoS Medicine·Jamie J KirkhamPaula R Williamson
Dec 22, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C SongX Yang
Mar 3, 2018·Diabetes Research and Clinical Practice·N H ChoB Malanda
Oct 3, 2018·American Journal of Obstetrics and Gynecology·James M N DuffyRichard J McManus
Jul 25, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Omran A H MusaSuhail A Doi
Mar 21, 2020·Diabetologia·Aoife M EganUNKNOWN INSPIRED research group
Aug 23, 2020·Diabetes Research and Clinical Practice·Suhail A R DoiLukman Thalib

❮ Previous
Next ❯

Citations

Oct 11, 2021·BMC Pregnancy and Childbirth·Marie ÖsterbergMaria Jonsson

❮ Previous
Next ❯

Software Mentioned

COS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.