Core-Shell Biphasic Microspheres with Tunable Density of Shell Micropores Providing Tailorable Bone Regeneration

Tissue Engineering. Part a
Jia FuZhongru Gou

Abstract

We have developed the new core-shell bioceramic CSi-Sr4@CaP-px microspheres with tuning porous shell layer so that the biodegradation of both CSi-Sr4 core and CaP shell is readily adjusted synergistically. This is for the first time, to the best of our knowledge, that the bioceramic scaffolds concerning gradient distribution and microstructure-tailoring design is available for tailoring biodegradation and ion release (bioactivity) to optimizing osteogenesis. Furthermore, it is possibly helpful to develop new bioactive scaffold system for time-dependent tailoring bioactivity and microporous structure to significantly enhance bone regeneration and repair applications, especially in some non-load-bearing arbitrary 3D anatomical bone and teeth defects.

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Citations

Feb 27, 2020·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Songou ZhangWenqing Liang
Nov 23, 2019·Biomolecules·Saba Abdulghani, Geoffrey R Mitchell

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Methods Mentioned

BETA
thermal treatments
X-ray
scanning electron microscopy

Software Mentioned

Pro Plus
Image
Inveon Acquisition Workplace [
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