Core-shell hybrid nanogels for integration of optical temperature-sensing, targeted tumor cell imaging, and combined chemo-photothermal treatment

Biomaterials
Weitai WuShuiqin Zhou

Abstract

We report a class of core-shell structured hybrid nanogels to demonstrate the conception of integrating the functional building blocks into a single nanoparticle system for simultaneously optical temperature-sensing, cancer cell targeting, fluorescence imaging, and combined chemo-photothermal treatment. The hybrid nanogels were constructed by coating the Ag-Au bimetallic NP core with a thermo-responsive nonlinear poly(ethylene glycol) (PEG)-based hydrogel as shell, and semi-interpenetrating the targeting ligands of hyaluronic acid chains into the surface networks of gel shell. The Ag-Au NP core can emit strong visible fluorescence for imaging of mouse melanoma B16F10 cells. The reversible thermo-responsive volume phase transition of the nonlinear PEG-based gel shell cannot only modify the physicochemical environment of the Ag-Au NP core to manipulate the fluorescence intensity for sensing the environmental temperature change, but also provide a high loading capacity for a model anticancer drug temozolomide and offer a thermo-triggered drug release. The drug release can be induced by both the heat generated by external NIR irradiation and the temperature increase of local environmental media. The ability of the hybrid nanogels t...Continue Reading

References

May 23, 2001·Advanced Drug Delivery Reviews·J Siepmann, N A Peppas
Mar 26, 2003·Nature Materials·Yoshihisa OhkoAkira Fujishima
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·L R HirschJ L West
Aug 19, 2004·Journal of the American Chemical Society·Sander F WuisterAndries Meijerink
Apr 14, 2005·Nano Letters·Christopher LooRebekah Drezek
Oct 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Haifeng WangJi-Xin Cheng
Feb 9, 2006·Journal of the American Chemical Society·Xiaohua HuangMostafa A El-Sayed
Sep 29, 2006·The Journal of Physical Chemistry. B·Kyeong-Seok Lee, Mostafa A El-Sayed
Nov 17, 2006·Pharmaceutical Research·V P Torchilin
Jan 24, 2007·Journal of Colloid and Interface Science·Jun YangHeng-Phon Too
May 10, 2007·International Journal of Cancer. Journal International Du Cancer·Chengli SongAlastair Thompson
Aug 28, 2007·Journal of the American Chemical Society·Jacob D GibsonEugene R Zubarev
Dec 25, 2007·Analytical and Bioanalytical Chemistry·Pedro BaptistaRicardo Franco
May 30, 2008·Advanced Drug Delivery Reviews·Jason R McCarthy, Ralph Weissleder
Jun 17, 2008·Advanced Drug Delivery Reviews·Partha GhoshVincent M Rotello
Jul 23, 2008·Journal of the American Chemical Society·Yu ChengClemens Burda
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Jul 26, 2008·Nature Nanotechnology·Wen JiangWarren C W Chan
Aug 5, 2008·Molecular Pharmaceutics·Frank AlexisOmid C Farokhzad
Sep 3, 2008·Chemical Society Reviews·Robert Wilson
Nov 29, 2008·Angewandte Chemie·Ramon A Alvarez-PueblaLuis M Liz-Marzán
Dec 5, 2008·Accounts of Chemical Research·Surbhi LalNaomi J Halas
Jan 13, 2009·Journal of the American Chemical Society·Chae Kyu KimVincent M Rotello
Feb 12, 2009·ACS Nano·Omid C Farokhzad, Robert Langer
Apr 9, 2009·Journal of the American Chemical Society·Sarit S AgastiVincent M Rotello
Jul 10, 2009·Chemical Society Reviews·Elodie Boisselier, Didier Astruc
Jul 31, 2009·Nano Letters·Elena A RozhkovaTijana Rajh
Aug 27, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Chenglin ChiZhibing Hu
Sep 24, 2009·Journal of the American Chemical Society·Jutaek NamSungjee Kim
Oct 1, 2009·Journal of the American Chemical Society·Luca MarettiJuan C Scaiano
Jun 11, 2008·Nanotechnology·Amanda M SchrandSaber M Hussain

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Citations

Sep 21, 2013·Biomaterials·Jing ZhouFuyou Li
May 7, 2013·Analytical Chemistry·Xia CaoYuanhua Shao
Aug 25, 2011·Chemical Communications : Chem Comm·Zesheng AnGuangyao Liu
Jan 1, 2010·Nano Reviews·Weitai Wu, Shuiqin Zhou
Mar 9, 2013·Theranostics·Jyothi U MenonKytai T Nguyen
Apr 5, 2012·Nanomedicine·Serguei Vinogradov, Xin Wei
Oct 15, 2013·Therapeutic Delivery·Akiko KiriyamaNobuhito Shibata
Dec 24, 2011·Nanomedicine·Esther Amstad, Erik Reimhult
Nov 12, 2013·Biotechnology Advances·Yu GaoLee Jia
Feb 5, 2014·Advances in Colloid and Interface Science·Krishnendu ChatterjeeSantanu Paria
Jun 7, 2014·Nanoscale·Paolo MatteiniRoberto Pini
Jun 25, 2014·Biomaterials·Tingting DaiGuangdong Zhou
Dec 9, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·D M EckmannV R Muzykantov
Mar 17, 2011·Nanoscale·Isabel Díez, Robin H A Ras
Jul 6, 2012·Nanoscale·Carlos D S BritesLuís D Carlos
Jun 25, 2013·Chemical Society Reviews·Xu-dong WangRobert J Meier
Feb 13, 2016·Advanced Materials·Yasser KhanAna C Arias
Apr 5, 2014·Drug Metabolism Reviews·Anamaria OrzaAlexandru Biris
Apr 23, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Xinghua SunAndre M Gobin
Sep 18, 2015·Macromolecular Rapid Communications·Weiren ChengYe Liu
Jan 20, 2016·Advances in Colloid and Interface Science·Benjamin Sierra-Martin, Antonio Fernandez-Barbero
Jan 4, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Jun LiJuan Tao
Jul 12, 2016·Materials Horizons·Minnie Chan, Adah Almutairi
Mar 5, 2016·Chemical Communications : Chem Comm·Aiping ChangWeitai Wu
Dec 9, 2015·Nano Today·Alina Y RweiDaniel S Kohane
Sep 16, 2015·Soft Matter·B Sierra-Martin, A Fernandez-Barbero
Jul 12, 2013·Biotechnology Journal·Madhura Joglekar, Brian G Trewyn
Aug 12, 2015·Chemical Reviews·Yulin LiHelena Tomás
Aug 3, 2013·Colloids and Surfaces. B, Biointerfaces·Qian TaoLinqi Shi
Mar 20, 2015·Drug Delivery and Translational Research·James T Cole, Nolan B Holland

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