Core-Shell Structure of Monodisperse Poly(ethylene glycol)-Grafted Iron Oxide Nanoparticles Studied by Small-Angle X-ray Scattering.

Chemistry of Materials : a Publication of the American Chemical Society
Tilman A GrünewaldErik Reimhult

Abstract

The promising applications of core-shell nanoparticles in the biological and medical field have been well investigated in recent years. One remaining challenge is the characterization of the structure of the hydrated polymer shell. Here we use small-angle X-ray scattering (SAXS) to investigate iron oxide core-poly(ethylene glycol) brush shell nanoparticles with extremely high polymer grafting density. It is shown that the shell density profile can be described by a scaling model that takes into account the locally very high grafting density near the core. A good fit to a constant density region followed by a star-polymer-like, monotonously decaying density profile is shown, which could help explain the unique colloidal properties of such densely grafted core-shell nanoparticles. SAXS experiments probing the thermally induced dehydration of the shell and the response to dilution confirmed that the observed features are associated with the brush and not attributed to structure factors from particle aggregates. We thereby demonstrate that the structure of monodisperse core-shell nanoparticles with dense solvated shells can be well studied with SAXS and that different density models can be distinguished from each other.

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Citations

Feb 5, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Sabina MaskeyGary S Grest
Aug 14, 2015·ACS Applied Materials & Interfaces·Steffen KurzhalsErik Reimhult
Apr 6, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Andrea LassenbergerErik Reimhult
Mar 8, 2018·Advanced Materials·Lukas MichalekChristopher Barner-Kowollik
Sep 13, 2018·Materials·Martina Schroffenegger, Erik Reimhult
Jan 5, 2021·ACS Applied Materials & Interfaces·Elia RomaTecla Gasperi
Dec 27, 2019·Chemistry of Materials : a Publication of the American Chemical Society·Daniele SelliCristiana Di Valentin
Mar 13, 2017·ACS Biomaterials Science & Engineering·Noga GalErik Reimhult
Mar 20, 2019·Chemistry of Materials : a Publication of the American Chemical Society·Katherine P BarteauUlrich Wiesner
Oct 1, 2019·Analytical Chemistry·Sarah E SandlerO Thompson Mefford
May 1, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Erik ReimhultAndrea Lassenberger

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Methods Mentioned

BETA
small-angle neutron scattering
SANS
X-ray
transmission
dynamic

Software Mentioned

SAS
SaxsGui
Mathematica
Mettler
SANS
Pebbles
Toledo

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