Core-shell structured gel-nanocarriers for sustained drug release and enhanced antitumor effect

International Journal of Pharmaceutics
Wei HeLifang Yin

Abstract

The present paper attempted to develop temperature-sensitive and core-shell structured gel-nanocarriers (gel-NCs) for paclitaxel (PTX) with 12-hydroxystearic acid (12-HSA) as an organic gelator, which aims at sustaining drug release over time and thus improves the therapeutic effect. The gel-NCs were prepared by a mechanical mixing and high-pressure homogenization method. The gelation transition temperature (Tgel) of the organic phase contained in the cores of the gel-NCs was optimized by a stirring method. The gel-NCs were characterized in terms of the particle size, morphology and in vitro drug release. The in vivo studies, including the antitumor effects on H22 tumor-bearing mice, biocompatibility and toxicity in mice, were performed. Gel-NCs with approximately 170 nm were prepared successfully, and the gelation of the liquid cores at 37°C was achieved, while the amount of gelator was 3.75% (w/w). Due to the gelation of the cores, sustained drug release over time was obtained. Moreover, the PTX-loaded gel-NCs suppressed tumor growth more efficiently than the conventional nanocarriers with better in vivo biocompatibility and no toxicity to other healthy organs. In conclusion, the 12-HSA organogel-based NCs appear to be promis...Continue Reading

References

Feb 22, 1979·Nature·P B SchiffS B Horwitz
Feb 20, 2002·Chemical Reviews·Pierre Terech, Richard G. Weiss
Aug 29, 2002·Critical Reviews in Therapeutic Drug Carrier Systems·Patrick CouvreurChristine Vauthier
Nov 22, 2005·Expert Opinion on Drug Delivery·Sudaxshina Murdan
Aug 16, 2006·Accounts of Chemical Research·Mathew George, Richard G Weiss
Aug 9, 2007·Advanced Drug Delivery Reviews·Jaspreet K Vasir, Vinod Labhasetwar
Aug 19, 2007·Pharmaceutical Research·Anda VintiloiuJean-Christophe Leroux
Dec 18, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anda Vintiloiu, Jean-Christophe Leroux
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Aug 14, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Wanyu ChenAmy Q Shen
Sep 30, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Taher NassarSimon Benita
Mar 11, 2010·International Journal of Pharmaceutics·Jana Pardeike, Rainer H Müller
Mar 12, 2010·Journal of the American Chemical Society·Youqing ShenWilliam J Murdoch
Jul 10, 2010·Nature Reviews. Drug Discovery·Robby A Petros, Joseph M DeSimone
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos
Nov 17, 2010·Journal of the American Chemical Society·Sang-Min LeeSonBinh T Nguyen
Aug 11, 2011·International Journal of Pharmaceutics·Paolo BlasiMaurizio Ricci
Feb 22, 2012·International Journal of Pharmaceutics·Hao-Jun RongYuan-Yuan Shen
Apr 3, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lei GaoXiang Li
Jun 6, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qihang SunYouqing Shen
Sep 20, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Stěpán Koudelka, Jaroslav Turánek
Jan 8, 2013·Expert Opinion on Drug Delivery·Zhiping ZhangSi-Shen Feng
Feb 12, 2013·International Journal of Pharmaceutics·Wei HeWei Wu
Jul 23, 2013·International Journal of Pharmaceutics·Bei ZhangWei Wu
Aug 27, 2013·Colloids and Surfaces. B, Biointerfaces·Rajavelu Murali SankarSellamuthu N Jaisankar
Sep 26, 2013·Colloids and Surfaces. B, Biointerfaces·Ezequiel BernabeuDiego A Chiappetta
Nov 26, 2013·Advanced Drug Delivery Reviews·Swati Biswas, Vladimir P Torchilin
May 28, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jayaganesh V NatarajanSubbu Venkatraman
Sep 23, 2014·International Journal of Pharmaceutics·Maria Chiara GiuffridaMaria Grazia Sarpietro

❮ Previous
Next ❯

Citations

Jul 15, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jacob N LockhartEva Harth
Sep 8, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jacob N LockhartEva Harth
May 11, 2016·Pharmaceutical Research·Zhiqiang TianWei Wu
Jan 23, 2018·Chemical Society Reviews·Judith MayrDavid Díaz Díaz
Oct 28, 2015·Chemical Society Reviews·Maria MolinaMarcelo Calderón

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.