Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain.

Nature Structural & Molecular Biology
Daesung KimSepideh Khorasanizadeh

Abstract

MSL3 resides in the MSL (male-specific lethal) complex, which upregulates transcription by spreading the histone H4 Lys16 (H4K16) acetyl mark. We discovered a DNA-dependent interaction of MSL3 chromodomain with the H4K20 monomethyl mark. The structure of a ternary complex shows that the DNA minor groove accommodates the histone H4 tail, and monomethyllysine inserts in a four-residue aromatic cage in MSL3. H4K16 acetylation antagonizes MSL3 binding, suggesting that MSL function is regulated by a combination of post-translational modifications.

References

Oct 3, 2000·Nature·A AkhtarP B Becker
Feb 23, 2002·Science·Steven A Jacobs, Sepideh Khorasanizadeh
Jun 21, 2005·The Journal of Biological Chemistry·Peter R NielsenErnest D Laue
Dec 24, 2005·Nature·John F FlanaganSepideh Khorasanizadeh
Jan 18, 2006·EMBO Reports·Jeesun KimMark T Bedford
Feb 27, 2007·Cell·Bing LiJerry L Workman
Dec 2, 2008·Nature·Vikas ChandraFraydoon Rastinejad
Feb 24, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Hongbo Yang, Craig A Mizzen
Nov 3, 2009·Current Opinion in Genetics & Development·John C Lucchesi

❮ Previous
Next ❯

Citations

Dec 6, 2012·Nature Structural & Molecular Biology·Catherine A MusselmanTatiana G Kutateladze
Jan 9, 2013·Nature Structural & Molecular Biology·Charlotte I WangMitzi I Kuroda
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Adam D WierAndrew P VanDemark
Jan 17, 2012·The Journal of Biological Chemistry·Weibin GongYingang Feng
Dec 19, 2012·Epigenomics·Wolfgang Fischle
May 7, 2013·Annual Review of Biochemistry·Dinshaw J Patel, Zhanxin Wang
May 9, 2012·Genetics Research International·Michael B WellsLaura M Custer
Aug 12, 2014·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Marcela M L Soruco, Erica Larschan
Apr 8, 2014·Pharmacology & Therapeutics·Yanli LiuJinrong Min
Nov 8, 2011·Current Opinion in Structural Biology·Sepideh Khorasanizadeh
Mar 8, 2011·Current Opinion in Structural Biology·Sebastian GlattChristoph W Müller
Feb 15, 2011·Current Opinion in Genetics & Development·Tobias Straub, Peter B Becker
May 21, 2011·Journal of Cellular Biochemistry·Garwin PichlerHeinrich Leonhardt
Apr 15, 2014·Biochimica Et Biophysica Acta·Catherine A MusselmanTatiana G Kutateladze
Apr 22, 2014·Biochimica Et Biophysica Acta·Jiamu Du, Dinshaw J Patel
Dec 24, 2011·Acta Biochimica Et Biophysica Sinica·Yuanyuan Li, Haitao Li
Apr 23, 2015·Current Opinion in Genetics & Development·Claudia Isabelle Keller, Asifa Akhtar
Jun 22, 2014·Current Opinion in Structural Biology·Dapeng ZhangL Aravind
Oct 4, 2014·Trends in Biochemical Sciences·Su Qin, Jinrong Min
Jul 15, 2017·Nature Communications·Emma A MorrisonCatherine A Musselman
Aug 29, 2018·Protein Science : a Publication of the Protein Society·Jon D FaughnChristine E Schaner Tooley
Nov 6, 2018·Nature Reviews. Genetics·Bilal N Sheikh, Asifa Akhtar
Oct 7, 2010·Critical Reviews in Biochemistry and Molecular Biology·Kyoko L Yap, Ming-Ming Zhou
Oct 26, 2011·Critical Reviews in Biochemistry and Molecular Biology·Bartlomiej J BlusSepideh Khorasanizadeh
Dec 6, 2012·Molecular BioSystems·Miroslav Nikolov, Wolfgang Fischle
May 18, 2013·Organic & Biomolecular Chemistry·I Kira AstakhovaJesper Wengel
Nov 18, 2011·Physical Chemistry Chemical Physics : PCCP·Fang QinHai-Feng Chen
Jan 1, 2019·Nucleic Acids Research·Katelyn E ConnellyEmily C Dykhuizen

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR
acetylation
transgenic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.