Nov 5, 2014

Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae

Frontiers in Cellular and Infection Microbiology
Ann Kathrin Heroven, Petra Dersch

Abstract

Deciphering the principles how pathogenic bacteria adapt their metabolism to a specific host microenvironment is critical for understanding bacterial pathogenesis. The enteric pathogenic Yersinia species Yersinia pseudotuberculosis and Yersinia enterocolitica and the causative agent of plague, Yersinia pestis, are able to survive in a large variety of environmental reservoirs (e.g., soil, plants, insects) as well as warm-blooded animals (e.g., rodents, pigs, humans) with a particular preference for lymphatic tissues. In order to manage rapidly changing environmental conditions and interbacterial competition, Yersinia senses the nutritional composition during the course of an infection by special molecular devices, integrates this information and adapts its metabolism accordingly. In addition, nutrient availability has an impact on expression of virulence genes in response to C-sources, demonstrating a tight link between the pathogenicity of yersiniae and utilization of nutrients. Recent studies revealed that global regulatory factors such as the cAMP receptor protein (Crp) and the carbon storage regulator (Csr) system are part of a large network of transcriptional and posttranscriptional control strategies adjusting metabolic c...Continue Reading

Mentioned in this Paper

Metabolic Process, Cellular
Pathogenic Aspects
Pathogenesis
Pathogenicity
Metabolic Networks and Pathways
Cyclic AMP Receptor Protein
Pathogenic Organism
Transcription, Genetic
Biological Adaptation
Yersinia enterocolitica antigen

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