Core/shell PLGA microspheres with controllable in vivo release profile via rational core phase design

Artificial Cells, Nanomedicine, and Biotechnology
Meiling YuHui Xu

Abstract

Highly soluble drugs tend to release from preparations at high speeds, which make them need to be taken at frequent intervals. Additionally, some drugs need to be controlled to release in vivo at certain periods, so as to achieve therapeutic effects. Thus, the objective of this study is to design injectable microparticulate systems with controllable in vivo release profile. Biodegradable PLGA was used as the matrix material to fabricate microspheres using the traditional double emulsification-solvent evaporation method as well as improved techniques, with gel (5% gelatine or 25% F127) or LP powders as the inner phases. Their physicochemical properties were systemically investigated. Microspheres prepared by modified methods had an increase in drug loading (15.50, 16.72, 15.66%, respectively) and encapsulation efficiencies (73.46, 79.42, 74.40%, respectively) when compared with traditional methods (12.01 and 57.06%). The morphology of the particles was characterized by optical microscope (OM) and scanning electron microscopy (SEM), and the amorphous nature of the encapsulated drug was confirmed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis. To evaluate their release behaviour, the in vitro degra...Continue Reading

References

Dec 10, 1999·Journal of Pharmaceutical Sciences·H Sah
Oct 6, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·T FreytagR Bodmeier
Jun 28, 2002·International Journal of Pharmaceutics·A H El-Kamel
Jan 16, 2003·Biomaterials·Thomas J Koob, Daniel J Hernandez
Oct 24, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Shruti ChopraSanjay K Motwani
Nov 17, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jae Hyung ParkKinam Park
Aug 19, 2008·International Journal of Pharmaceutics·Ming LiDenis Poncelet
Mar 17, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A Paillard-GiteauM C Venier-Julienne
Mar 23, 2011·Expert Opinion on Drug Metabolism & Toxicology·Michel Burnier, Grégoire Wuerzner
May 10, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fengbin YeJesper Østergaard
Apr 3, 2013·Journal of Microencapsulation·Amélie GaignauxKarim Amighi
Jul 19, 2013·Journal of Microencapsulation·Mirella FalconiIsabella Orienti
Apr 30, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Muhammad Sajid Hamid Akash, Kanwal Rehman
Aug 8, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Peng ZhaiDavid J Schreyer
Nov 2, 2015·International Journal of Pharmaceutics·Bing GuDiane J Burgess
Dec 26, 2015·International Journal of Pharmaceutics·Jie ShenDiane J Burgess
Jun 11, 2016·Journal of Colloid and Interface Science·Yi WeiGuanghui Ma
Feb 6, 2017·World Journal of Stem Cells·Kanya Honoki
Sep 1, 2017·Asian Journal of Pharmaceutical Sciences·Takashi OsamuraHirofumi Takeuchi

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Citations

Apr 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cornelia VasileMihaela Baican
Aug 28, 2021·International Journal of Pharmaceutics·Ju Hee KimSeong Hoon Jeong

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